Nigrostriatal and mesolimbic control of sleep-wake behavior in rat

被引：12

作者：

Qiu, Mei-Hong ^{[1
,2
,3
,4
]}

Zhong, Zhi-Gang ^{[1
,2
]}

Chen, Michael C. ^{[3
,4
]}

Lu, Jun ^{[3
,4
]}

机构：

[1] Fudan Univ, Shanghai Med Coll, Sch Basic Med Sci, Dept Neurobiol,Inst Basic Res Aging & Med, Rm 115,Bldg 7,138 YiXueYuan Rd, Shanghai 200032, Peoples R China

[2] Fudan Univ, Shanghai Med Coll, Sch Basic Med Sci, Dept Pharmacol, Rm 115,Bldg 7,138 YiXueYuan Rd, Shanghai 200032, Peoples R China

[3] Beth Israel Deaconess Med Ctr, Dept Neurol, 709 CLS,Blackfan Circle 3, Boston, MA 02115 USA

[4] Harvard Med Sch, 709 CLS,Blackfan Circle 3, Boston, MA 02115 USA

来源：

BRAIN STRUCTURE & FUNCTION | 2019年 / 224卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Nigrostriatal pathway; Mesolimbic pathway; Dopamine; Sleep; Wake; EEG; DOPAMINERGIC-NEURONS; BASAL GANGLIA; NUCLEUS; LESIONS; BRAIN; IDENTIFICATION; TRANSDUCTION; STIMULATION; DISORDERS; DELIVERY;

D O I：

10.1007/s00429-019-01921-w

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

The midbrain dopamine system via the dorsal and ventral striatum regulates a wide range of behaviors. To dissect the role of dopaminergic projections to the dorsal striatum (nigrostriatal projection) and ventral striatum (mesolimbic projection) in sleep-wake behavior, we selectively chemogenetically stimulated nigrostriatal or mesolimbic projections and examined the resulting effects on sleep in rats. Stimulation of nigrostriatal pathways increased sleep and EEG delta power, while stimulation of mesolimbic pathways decreased sleep and reduced cortical EEG power. These results indicate that midbrain dopamine signaling in the dorsal or ventral striatum promotes sleep or wake, respectively.

引用

页码：2525 / 2535

页数：11

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