Dominant behaviours in the expression of human carbonic anhydrase hCA I activity

被引：14

作者：

Abdelrahim, M. Yahia M. ^{[1
]}

Tanc, Muhammet ^{[2
]}

Winum, Jean-Yves ^{[3
]}

Supuran, Claudiu T. ^{[3
]}

Barboiu, Mihail ^{[1
]}

机构：

[1] ENSCM UMII UMR CNRS 5635, Inst Europeen Membranes, Adaptat Supramol Nanosyst Grp, F-34095 Montpellier 5, France

[2] Univ Florence, Lab Chim Bioinorgan, I-50019 Florence, Italy

[3] Ecole Natl Super Chim Montpellier, CNRS, UMR 5247, IBMM, F-34296 Montpellier, France

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 59期

关键词：

DYNAMIC COMBINATORIAL CHEMISTRY; DRUG DISCOVERY; ISOZYMES I; NEURAMINIDASE INHIBITORS; SUPRAMOLECULAR CHEMISTRY; LIBRARIES; ACTIVATORS; SELECTION; SITE; DERIVATIVES;

D O I：

10.1039/c4cc03289f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Here we describe the screening via Dynamic Deconvolution of DCLs of inhibitors (CAIs) and activators (CAAs) of hCA I. The inhibitory effects dominate over the activating ones, while the CAAs may be identified in the absence of CAIs.

引用

页码：8043 / 8046

页数：4

共 50 条

[1] Carbonic anhydrase inhibitors: Synthesis, characterization and inhibition activities of furan sulfonylhydrazones against carbonic anhydrase I (hCA I)
Gunduzalp, Ayla Balaban
Parlakgumus, Gokhan
Uzun, Demet
Ozmen, Ummuhan Ozdemir
Ozbek, Neslihan
Sari, Musa
Tunc, Tuncay
JOURNAL OF MOLECULAR STRUCTURE, 2016, 1105 : 332 - 340
[2] The human carbonic anhydrase isoenzymes I and II (hCA I and II) inhibition effects of trimethoxyindane derivatives
Taslimi, Parham
Gulcin, Ilhami
Ozgeris, Bunyamin
Goksu, Suleyman
Tumer, Ferhan
Alwasel, Saleh H.
Supuran, Claudiu T.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2016, 31 (01) : 152 - 157
[3] Carbonic anhydrase inhibitors: guaiacol and catechol derivatives effectively inhibit certain human carbonic anhydrase isoenzymes (hCA I, II, IX and XII)
Scozzafava, Andrea
Passaponti, Maurizio
Supuran, Claudiu T.
Gulcin, Ilhami
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2015, 30 (04) : 586 - 591
[4] Carbonic anhydrase inhibitors: in vitro inhibition of α isoforms (hCA I, hCA II, bCA III, hCA IV) by flavonoids
Ekinci, Derya
Karagoz, Lutfi
Ekinci, Deniz
Senturk, Murat
Supuran, Claudiu T.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2013, 28 (02) : 283 - 288
[5] Inhibition studies on mutant Phe91Asn human carbonic anhydrase I (HCA I) gene
Kockar, F.
Ayduen, M.
Turkoglu, S. A.
Arslan, O.
Turan, Y.
FEBS JOURNAL, 2008, 275 : 168 - 168
[6] Synthesis and evaluation of sulfonamide-bearing thiazole as carbonic anhydrase isoforms hCA I and hCA II
Kilicaslan, Soner
Arslan, Mustafa
Ruya, Zeynep
Bilen, Cigdem
Ergun, Adem
Gencer, Nahit
Arslan, Oktay
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2016, 31 (06) : 1300 - 1305
[7] Inhibitory Effects of Metabolites Isolated from Artemisia dracunculus L. Against the Human Carbonic Anhydrase I (hCA I) and II (hCA II)
Aydin, Tuba
Yurtvermez, Bayram
Senturk, Murat
Kazaz, Cavit
Cakir, Ahmet
RECORDS OF NATURAL PRODUCTS, 2019, 13 (03) : 216 - 225
[8] Synthesis and evaluation of new thiadiazole derivatives as potential inhibitors of human carbonic anhydrase isozymes (hCA-I and hCA-II)
Altintop, Mehlika Dilek
Ozdemir, Ahmet
Kucukoglu, Kaan
Turan-Zitouni, Gulhan
Nadaroglu, Hayrunnisa
Kaplancikli, Zafer Asim
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2015, 30 (01) : 32 - 37
[9] Identification of Potent and Selective Human Carbonic Anhydrase VII (hCA VII) Inhibitors
Gitto, Rosaria
Agnello, Stefano
Ferro, Stefania
Vulio, Daniela
Supuran, Claudiu T.
Chimirri, Alba
CHEMMEDCHEM, 2010, 5 (06) : 823 - 826
[10] QSAR study on the inhibition of the human carbonic anhydrase cytosolic isozyme hCA VII
Singh, Shalini
JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 2013, 90 (02) : 245 - 252

← 1 2 3 4 5 →