Synthesis, Crystal Structures, and Cytotoxic Activity of Two Acetyl Chroman Derivatives

被引：0
|
作者：
Hu, X. X. [1 ]
Huang, Z. F. [1 ]
Lu, G. S. [1 ]
Huang, J. Y. [1 ]
Li, X. N. [2 ]
Tan, X. [1 ]
Feng, D. [1 ]
机构：
[1] Guangxi Inst Tradit Med & Pharmaceut Sci, Key Lab Tradit Chinese Med Qual Stand, Nanning 530022, Peoples R China
[2] Chinese Acad Sci, Kunming Inst Bot, Kunming 650000, Peoples R China
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 58卷 / 12期
关键词：
acetyl chroman derivative; X-ray analysis; crystal structures; cytotoxicity;
D O I：
10.1134/S1070428022120156
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Two acetyl chroman derivative, 1-(5,7-dihydroxy-2,2-dimethylchroman-8-yl)ethan-1-one (1) and 1-(5,7-dihydroxy-2,2-dimethylchroman-6-yl)ethan-1-one (2) were synthesized as intermediate products in the preparation of flavonoids. Their structures were characterized by NMR and IR and confirmed by high-resolution mass spectra and single crystal X-ray analysis. The inhibitory effects of the synthesized compounds on the growth of A549, HepG2, SW480, and MCF-7 cancer cell lines were evaluated by the CCK8 methods. Compound 1 showed cytotoxicity against HepG2, SW480, and MCF-7 cell lines with IC50 values of 12.85, 23.94, and 28.72 mu M, respectively, and compound 2 showed cytotoxicity against HepG2 and MCF-7 cell lines with IC50 values of 24.78 and 23.87 mu M, respectively.
引用
收藏
页码：1861 / 1867
页数：7
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