Exercise-modulated epigenetic markers and inflammatory response in COPD individuals: A pilot study

被引：26
|
作者：
Vital da Silva, Ivy Reichert [1 ]
Pereira de Araujo, Cintia Laura [2 ]
Dorneles, Gilson Pires [3 ]
Peres, Alessandra [1 ,3 ]
Bard, Andreia Luciana [4 ]
Reinaldo, Gustavo [2 ]
Zimermann Teixeira, Paulo Jose [2 ,5 ]
Dal Lago, Pedro [2 ]
Elsner, Viviane Rostirola [1 ]
机构：
[1] Ctr Univ Metodista IPA, Programa Pos Grad Biociencias & Reabilitacao, Rua Coronel Joaquim Pedro Salgado 80, BR-90420060 Porto Alegre, RS, Brazil
[2] Univ Fed Ciencias Saude Porto, Programa Pos Grad Ciencias Saude, Porto Alegre, RS, Brazil
[3] Univ Fed Ciencias Saude Porto Alegre, Dept Hlth Basic Sci, Cellular & Mol Immunol Lab, Porto Alegre, RS, Brazil
[4] Ctr Univ Metodista IPA, Curso Fisioterapia, Porto Alegre, RS, Brazil
[5] Hosp Santa Casa Misericordia Porto Alegre, Med Responsavel Serv Reabilitacao Pulm Pavilhao P, Porto Alegre, RS, Brazil
来源：
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY | 2017年 / 242卷
关键词：
COPD; Exercise; Global histone H4 acetylation; Global DNA methylation; Inflammatory response; OBSTRUCTIVE PULMONARY-DISEASE; SYSTEMIC INFLAMMATION; DNA METHYLATION; CYTOKINE RESPONSE; MUSCLE; EXACERBATION; IMPACT;
D O I：
10.1016/j.resp.2017.04.004
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
The study investigated the effects of exercise on epigenetic signals and systemic cytokine levels in chronic obstructive pulmonary disease (COPD) individuals. Ten participants of a pulmonary rehabilitation program were submitted to 24 sessions of a supervisioned exercise protocol thrice-weekly (90 min/session). Blood samples were collected at baseline, after the 1st session, before and after the 24th session. A DNA hypomethylation status was observed after the 1st session when compared at baseline, while global histone H4 acetylation status was unaltered in any time-points evaluated. No significant changes were observed on cytokine levels after the 1st session. A significant enhancement on interleukin 6 (IL-6) and a decrease on transforming growth factor-beta (TGF-beta) levels were found after the 24th session when compared to the pre 24th session. Moreover, 23 sessions of exercise were able to diminish significantly the basal levels of IL-6 and interleukin 8 (IL-8). These data suggest a potential role of epigenetic machinery in mediating the anti-inflammatory effects of exercise in COPD patients.
引用
收藏
页码：89 / 95
页数：7
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