Efficient solid-phase synthesis of 4,5-dihydro-1,2,4-triazin-6(1H)-ones

被引：9
|
作者：
Boeglin, D
Cantel, S
Martinez, J
Fehrentz, JA
机构：
[1] Univ Montpellier 1, CNRS, Fac Pharm, UMR 5810,LAPP, F-34093 Montpellier 5, France
[2] Univ Montpellier 2, CNRS, Fac Pharm, UMR 5810,LAPP, F-34093 Montpellier 5, France
来源：
TETRAHEDRON LETTERS | 2003年 / 44卷 / 03期
关键词：
Lawesson's reagent; 4,5-dihydrotriazin-6-one; thioamide; cyclocleavage;
D O I：
10.1016/S0040-4039(02)02591-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new and easy protocol for the formation of substituted 4,5-dihydro-1,2,4-triazin-6(1H)-ones was developed on solid support. The heterocyclic compounds were formed by nucleophilic reaction of hydrazine on thioamide esters. As cyclization was concomitant with cleavage from the support, substituted 4,5-dihydrotriazinones were obtained in high purity. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：459 / 462
页数：4
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