Cobalamin-binding proteins in normal and cobalamin-deficient older subjects

被引:7
|
作者
van Asselt, DZB
Thomas, CMG
Segers, MFG
Blom, HJ
Wevers, RA
Hoefnagels, WHL
机构
[1] Univ Nijmegen, Med Ctr, Dept Geriatr Med, Nijmegen, Netherlands
[2] Univ Nijmegen, Med Ctr, Dept Chem Endocrinol, Nijmegen, Netherlands
[3] Univ Nijmegen, Med Ctr, Dept Pediat & Neurol, Nijmegen, Netherlands
关键词
D O I
10.1258/000456303321016187
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Background The causes of cobalamin (vitamin B-12) deficiency in older people are only partly understood. We investigated the role of the cobalamin-binding proteins and tested the hypothesis that low saturated transcobalamin concentration is an early marker of cobalamin deficiency. Methods We measured saturated (holo) and unsaturated (apo) transcobalamin and haptocorrin concentrations in healthy middle-aged volunteers, healthy older volunteers, cobalamin-deficient older volunteers and cobalamin-deficient older patients. Results Holo and apo concentrations of transcobalamin and haptocorrin were similar in healthy middle-aged and older subjects. Holotranscobalamin concentrations were significantly decreased in cobalamin-deficient subjects but did not differ between healthy volunteers and patients. Furthermore, the relative amount of cobalamin on transcobalamin (i.e. holotranscobalamin/holotranscobalamin + holohaptocorrin) was similar in all four groups. Conclusions Abnormalities of the cobalamin-binding proteins are not a cause of cobalamin deficiency in the aged. Plasma holotranscobalamin concentration did not differ between stages of cobalamin deficiency in older persons. Therefore, plasma holotranscobalamin is not an early marker of cobalamin deficiency in older people and has no additional value in the diagnostic work-up of reduced plasma cobalamin concentrations in older people.
引用
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页码:65 / 69
页数:5
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