Production of β-Maltooligosaccharides of α- and δ-Tocopherols by Klebsiella pneumoniae and Cyclodextrin Glucanotransferase as Anti-allergic Agents

被引：10
|
作者：
Shimoda, Kei [1 ]
Akagi, Masaaki [2 ]
Hamada, Hiroki [3 ]
机构：
[1] Oita Univ, Dept Chem, Fac Med, Oita 8795593, Japan
[2] Tokushima Bunri Univ, Dept Pharmacol, Fac Pharmaceut Sci, Yamashiro, Tokushima 7708514, Japan
[3] Okayama Univ Sci, Dept Life Sci, Okayama 7000005, Japan
来源：
MOLECULES | 2009年 / 14卷 / 08期
关键词：
tocopherol; Klebsiella pneumoniae; cyclodextrin glucanotransferase; beta-maltooligosaccharide; anti-allergic activity; VITAMIN-E CONSUMPTION; ANTIOXIDANT; METABOLISM; DISEASE; DRUGS; RISK;
D O I：
10.3390/molecules14083106
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The glycosylation of alpha- and delta-tocopherols using Klebsiella pneumoniae and cyclodextrin glucanotransferase (CGTase) was investigated. K. pneumoniae converted alpha- and delta-tocopherols into the corresponding beta-glucosides in 10 and 8% yield, respectively. CGTase glycosylated alpha-tocopheryl beta-glucoside to alpha-tocopheryl beta-maltoside (51%) and alpha-tocopheryl beta-maltotrioside (35%). On the other hand, delta-tocopheryl beta-glucoside was converted into the corresponding beta-maltoside (45%) and beta-maltotrioside (29%) by CGTase. The beta-glucoside of alpha-tocopherol, and beta-glucoside and beta-maltoside of delta-tocopherol showed inhibitory effects on IgE antibody production and on histamine release from rat peritoneal mast cells.
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页码：3106 / 3114
页数：9
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