Molecular genetics of age-related cataract

被引：101
|
作者：
Hejtmancik, JF
Kantorow, M
机构：
[1] Florida Atlantic Univ, Dept Biomed Sci, Boca Raton, FL 33431 USA
[2] NEI, Ophthalm Genet & Visual Funct Branch, Bethesda, MD 20892 USA
来源：
EXPERIMENTAL EYE RESEARCH | 2004年 / 79卷 / 01期
关键词：
lens; cataract; genetics; gene expression;
D O I：
10.1016/j.exer.2004.03.014
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Advances in molecular biological and genetic technology have greatly accelerated elucidation of the genetic contribution to age-related cataract. Epidemiological studies have documented tendencies for cataracts to occur more frequently in relatives of cataract patients than in the general population, genetic studies have demonstrated contributory roles of some specific genes in age related cataract in small populations. and molecular studies have shown changes in expression of specific genes in cataractous lenses. Together, these studies are beginning to provide a conceptual framework for understanding age-related cataracts. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3 / 9
页数：7
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