Dual selective iron chelating probes with a potential to monitor mitochondrial labile iron pools

被引：26
|
作者：
Abbate, Vincenzo [1 ]
Reelfs, Olivier [2 ]
Kong, Xiaole [1 ]
Pourzand, Charareh [2 ]
Hider, Robert C. [1 ]
机构：
[1] Kings Coll London, Inst Pharmaceut Sci, London SE1 9NH, England
[2] Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England
来源：
CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 04期
基金：
英国生物技术与生命科学研究理事会;
关键词：
PEPTIDE ANTIOXIDANTS; OXIDATIVE STRESS; ULTRAVIOLET; RADIATION; DISEASE; DESIGN;
D O I：
10.1039/c5cc06170a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Mitochondria-targeted peptides incorporating dual fluorescent and selective iron chelators have been designed as novel biosensors for the mitochondrial labile iron pool. The probes were demonstrated to specifically co-localize with mitochondria and their fluorescence emission was found to be sensitive to the presence of iron.
引用
收藏
页码：784 / 787
页数：4
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