The molecular basis of insecticide resistance in mosquitoes

被引：840

作者：

Hemingway, J ^{[1
]}

Hawkes, NJ ^{[1
]}

McCarroll, L ^{[1
]}

Ranson, H ^{[1
]}

机构：

[1] Univ Liverpool, Liverpool Sch Trop Med, Liverpool L3 5QA, Merseyside, England

来源：

INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2004年 / 34卷 / 07期

关键词：

esterase; insecticide resistance; molecular mechanism; glutathione S-transferase (GST); GABA; rdl; sodium channel; kdr; carboxylesterase; p450; monooxygenase; acetylcholinesterase;

D O I：

10.1016/j.ibmb.2004.03.018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Insecticide resistance is an inherited characteristic involving changes in one or more insect gene. The molecular basis of these changes are only now being fully determined, aided by the availability of the Drosophila melanogaster and Anopheles gambiae genome sequences. This paper reviews what is currently known about insecticide resistance conferred by metabolic or target site changes in mosquitoes. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：653 / 665

页数：13

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