Waldenstrom's macroglobulinemia

被引：30
|
作者：
Dimopoulos, MA [1 ]
Galani, E [1 ]
Matsouka, C [1 ]
机构：
[1] Univ Athens, Sch Med, Dept Clin Therapeut, GR-11527 Athens, Greece
来源：
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 1999年 / 13卷 / 06期
关键词：
D O I：
10.1016/S0889-8588(05)70130-1
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The clinical manifestations of Waldenstrom's macroglobulinemia are related to direct tumor infiltration and to the unique properties of the immunoglobulin M monoclonal protein. Plasmaphereses usually combined with systemic chemotherapy provide effective palliation for most patients. Standard treatment consists of oral chlorambucil, but the nucleoside analogues cladribine and fludarabine are very active in this disease. These agents are the treatment of choice in patients with disease that is resistant to alkylating agents.
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收藏
页码：1351 / +
页数：17
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