Influence of Prior Influenza Vaccination on Current Influenza Vaccine Effectiveness in Children Aged 1 to 5 Years

被引:4
|
作者
Matsumoto, Kazuhiro [1 ]
Fukushima, Wakaba [1 ,2 ]
Morikawa, Saeko [3 ]
Fujioka, Masashi [4 ]
Matsushita, Tohru [5 ]
Kubota, Megumi [6 ]
Yagi, Yoshina [7 ]
Takasaki, Yoshio [8 ]
Shindo, Shizuo [9 ]
Yamashita, Yuji [10 ]
Yokoyama, Takato [11 ]
Kiyomatsu, Yumi [12 ]
Hiroi, Satoshi [3 ]
Nakata, Keiko [3 ]
Maeda, Akiko [1 ]
Kondo, Kyoko [13 ]
Ito, Kazuya [1 ,2 ,14 ,15 ]
Kase, Tetsuo [1 ,2 ]
Ohfuji, Satoko [1 ,2 ]
Hirota, Yoshio [15 ]
机构
[1] Osaka City Univ, Grad Sch Med, Dept Publ Hlth, Osaka 5458585, Japan
[2] Osaka City Univ, Grad Sch Med, Res Ctr Infect Dis Sci, Osaka 5458585, Japan
[3] Osaka Inst Publ Hlth, Dept Virol, Osaka 5370025, Japan
[4] Fujioka Pediat Clin, Tondabayashi 5840074, Japan
[5] Matsushita Kids Clin, Kadoma, Osaka 5710030, Japan
[6] Kubota Childrens Clin, Osaka 5440033, Japan
[7] Yagi Pediat Clin, Yao 5810871, Japan
[8] Takasaki Pediat Clin, Fukuoka 8190052, Japan
[9] Shindo Childrens Clin, Fukuoka 8140121, Japan
[10] Yamashita Pediat Clin, Itoshima 8191112, Japan
[11] Yokoyama Childrens Clin, Kasuga, Fukuoka 8160801, Japan
[12] Kiyomatsu Pediat Clin, Fukuoka 8140021, Japan
[13] Osaka City Univ Hosp, Management Bur, Osaka 5458586, Japan
[14] Coll Healthcare Management, Healthcare Management, Miyama 8350018, Japan
[15] SOUSEIKAI, Clin Epidemiol Res Ctr, Fukuoka 8130017, Japan
关键词
influenza; repeated vaccination; test-negative design; IMPACT; VIRUS; HOSPITALIZATION; POPULATION; EFFICACY; IMMUNITY; A(H3N2); SEASON;
D O I
10.3390/vaccines9121447
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background: Although annual influenza vaccination is an important strategy used to prevent influenza-related morbidity and mortality, some studies have reported the negative influence of prior vaccination on vaccine effectiveness (VE) for current seasons. Currently, the influence of prior vaccination is not conclusive, especially in children. Methods: We evaluated the association between current-season VE and prior season vaccination using a test-negative design in children aged 1-5 years presenting at nine outpatient clinics in Japan during the 2016/17 and 2017/18 influenza seasons. Children with influenza-like illness were enrolled prospectively and tested for influenza using real-time RT-PCR. Their recent vaccination history was categorized into six groups according to current vaccination doses (0/1/2) and prior vaccination status (unvaccinated = 0 doses/vaccinated = 1 dose or 2 doses): (1) 0 doses in the current season and unvaccinated in prior seasons (reference group); (2) 0 doses in the current season and vaccinated in a prior season; (3) 1 dose in the current season and unvaccinated in a prior season; (4) 1 dose in the current season and vaccinated in a prior season; (5) 2 doses in the current season and unvaccinated in a prior season, and (6) 2 doses in the current season and vaccinated in a prior season. Results: A total of 799 cases and 1196 controls were analyzed. The median age of the subjects was 3 years, and the proportion of males was 54%. Overall, the vaccination rates (any vaccination in the current season) in the cases and controls were 36% and 53%, respectively. The VEs of the groups were: (2) 29% (95% confidence interval: -25% to 59%); (3) 53% (6% to 76%); (4) 70% (45% to 83%); (5) 56% (32% to 72%), and (6) 61% (42% to 73%). The one- and two-dose VEs of the current season were significant regardless of prior vaccination status. The results did not differ when stratified by influenza subtype/lineage. Conclusion: Prior vaccination did not attenuate the current-season VE in children aged 1 to 5 years, supporting the annual vaccination strategy.
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页数:11
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