RPA puts the brakes on MMEJ

被引：10

作者：

McVey, Mitch ^{[1
]}

机构：

[1] Tufts Univ, Dept Biol, Medford, MA 02155 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2014年 / 21卷 / 04期

关键词：

DOUBLE-STRAND BREAKS; REPLICATION PROTEIN-A; END-JOINING PATHWAY; SACCHAROMYCES-CEREVISIAE; HOMOLOGOUS RECOMBINATION; DNA; REPAIR; RESECTION; SEQUENCES; COMPLEX;

D O I：

10.1038/nsmb.2802

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Microhomology-mediated end joining (MMEJ) is a mechanism of DNA double-strand-break repair that creates deletions and promotes other types of genome instability. New in vivo and in vitro analyses demonstrate that the heterotrimeric replication protein A (RPA) complex prevents spontaneous annealing of microhomologies, thereby preventing genome-destabilizing MMEJ.

引用

页码：348 / 349

页数：3

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