Metal-Free Tandem Approach for Triazole-Fused Diazepinone Scaffolds via [3+2]Cycloaddition/C-N Coupling Reaction

被引：10

作者：

Majeed, Kashif ^{[1
]}

Wang, Lingna ^{[1
]}

Liu, Bangjie ^{[1
]}

Guo, Zijian ^{[1
]}

Zhou, Fengtao ^{[1
]}

Zhang, Qiuyu ^{[1
]}

机构：

[1] Northwestern Polytech Univ, Sch Chem & Chem Engn, Dept Appl Chem, Xian Key Lab Funct Organ Porous Mat, Xian 710072, Shaanxi, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 86卷 / 01期

基金：

中国国家自然科学基金;

关键词：

ONE-POT SYNTHESIS; CLICK CHEMISTRY; DISCOVERY; N-(2-HALOARYL)PROPIOLAMIDES; DESIGN;

D O I：

10.1021/acs.joc.0c02022

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel metal-free, efficient cascade reaction has been developed to construct 1,2,3-triazole-fused 1,4-diazepinone skeletons. Mechanism investigation indicated that sodium azide has not only served as a 1,3-dipoles synthon in [3 + 2] cycloaddition but also prompted C-N bond formation. Furthermore, the potential utility of this protocol was demonstrated by scale-up synthesis of 1,2,3-triazole-fused diazepinone derivatives and the derivatization of them.

引用

页码：207 / 222

页数：16

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