Synthesis of halogenated derivatives of thymol and their antimicrobial activities

被引：27
|
作者：
Kaur, Ranjeet [1 ]
Darokar, Mahendra P. [2 ]
Chattopadhyay, Sunil Kumar [1 ]
Krishna, Vinay [2 ]
Ahmad, Ateeque [1 ]
机构：
[1] CSIR, Cent Inst Med & Aromat Plants, Proc Chem & Chem Engn Dept, Lucknow 226015, Uttar Pradesh, India
[2] CSIR, Cent Inst Med & Aromat Plants, Genet Resource Biotechnol Dept, Lucknow 226015, Uttar Pradesh, India
来源：
MEDICINAL CHEMISTRY RESEARCH | 2014年 / 23卷 / 05期
关键词：
Thymol derivatives; N-Halosuccinimide; Antibacterial activity; Antifungal activity;
D O I：
10.1007/s00044-013-0809-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In order to test the antibacterial and antifungal activities of different halogenated thymol derivatives, thymol has been converted into chlorothymol, dichlorothymol with N-chlorosuccinimide; monobromothymol, dibromothymol with N-bromosuccinimide; O-methylated iodothymol with ceric ammonium nitrate and iodine from methylated thymol. Among the different derivatives tested, 4-chlorothymol was found to be most active against Staphylococcus aureus and Staphylococcus epidermis at a concentration of 12.5 and 25 ppm, respectively. Also it was tested to be active against Candida albicans (AI).
引用
收藏
页码：2212 / 2217
页数：6
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