Blood biomarkers and treatment response in major depression
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作者:
Mora, Cristina
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IRCCS Fatebenefratelli S Giovanni di Dio, Biol Psychiat Unit, Brescia, ItalyIRCCS Fatebenefratelli S Giovanni di Dio, Biol Psychiat Unit, Brescia, Italy
Mora, Cristina
[1
]
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Zonca, Valentina
[1
,2
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Riva, Marco A.
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机构:
Univ Milan, Dept Pharmacol & Biomol Sci, Milan, ItalyIRCCS Fatebenefratelli S Giovanni di Dio, Biol Psychiat Unit, Brescia, Italy
Riva, Marco A.
[2
]
Cattaneo, Annamaria
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IRCCS Fatebenefratelli S Giovanni di Dio, Biol Psychiat Unit, Brescia, Italy
Kings Coll London, Stress Psychiat & Immunol Lab, Dept Psychol Med, Inst Psychiat, London, EnglandIRCCS Fatebenefratelli S Giovanni di Dio, Biol Psychiat Unit, Brescia, Italy
Cattaneo, Annamaria
[1
,3
]
机构:
[1] IRCCS Fatebenefratelli S Giovanni di Dio, Biol Psychiat Unit, Brescia, Italy
Introduction: Millions of people worldwide suffer from depression, but despite advances in pharmacological therapies, many patients do not experience symptomatic remission or treatment response, even after treatments with several medications. As such, there is an urgent need to identify biomarkers that can not only predict the treatment response but also allow a rational selection of optimal therapy for each patient.Areas covered: This review examines the recent findings, coming from different omic sciences,' in human blood-based biomarkers associated with antidepressant treatment response with particular attention on genetic/epigenetic and biochemical biomarkers. Specific emphasis will be placed on key molecules related to neuroplasticity and inflammation because of their involvement in the pathophysiology of depression and antidepressant response.Expert commentary: Biomarker identification is still an ongoing work. Indeed, to date, no biomarkers have sufficiently proven specificity, sensitivity, and reproducibility to be used in the clinical setting. However, omic' approaches hold great promise in identifying multiple features for predicting antidepressant response, making a personalized treatment strategy possible for each patient, and thereby assist with quick and efficacious responsiveness. It is thus necessary that future studies take an integrative approach that includes clinical assessment, environment influences, and molecular and biological biomarkers.
机构:
Icahn Sch Med Mt Sinai, Mood & Anxiety Disorders Program, Dept Psychiat, New York, NY 10029 USAIcahn Sch Med Mt Sinai, Mood & Anxiety Disorders Program, Dept Psychiat, New York, NY 10029 USA
机构:
UT Southwestern Med Ctr, Dept Psychiat, Ctr Depress Res & Clin Care, Dallas, TX USAUT Southwestern Med Ctr, Dept Psychiat, Ctr Depress Res & Clin Care, Dallas, TX USA
Gadad, Bharathi S.
Jha, Manish K.
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UT Southwestern Med Ctr, Dept Psychiat, Ctr Depress Res & Clin Care, Dallas, TX USAUT Southwestern Med Ctr, Dept Psychiat, Ctr Depress Res & Clin Care, Dallas, TX USA
Jha, Manish K.
Czysz, Andrew
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UT Southwestern Med Ctr, Dept Psychiat, Ctr Depress Res & Clin Care, Dallas, TX USAUT Southwestern Med Ctr, Dept Psychiat, Ctr Depress Res & Clin Care, Dallas, TX USA
Czysz, Andrew
Furman, Jennifer L.
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UT Southwestern Med Ctr, Dept Psychiat, Ctr Depress Res & Clin Care, Dallas, TX USAUT Southwestern Med Ctr, Dept Psychiat, Ctr Depress Res & Clin Care, Dallas, TX USA
Furman, Jennifer L.
Mayes, Taryn L.
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机构:
UT Southwestern Med Ctr, Dept Psychiat, Ctr Depress Res & Clin Care, Dallas, TX USAUT Southwestern Med Ctr, Dept Psychiat, Ctr Depress Res & Clin Care, Dallas, TX USA
Mayes, Taryn L.
Emslie, Michael P.
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机构:
UT Southwestern Med Ctr, Dept Psychiat, Ctr Depress Res & Clin Care, Dallas, TX USAUT Southwestern Med Ctr, Dept Psychiat, Ctr Depress Res & Clin Care, Dallas, TX USA
Emslie, Michael P.
Trivedi, Madhukar H.
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UT Southwestern Med Ctr, Dept Psychiat, Ctr Depress Res & Clin Care, Dallas, TX USAUT Southwestern Med Ctr, Dept Psychiat, Ctr Depress Res & Clin Care, Dallas, TX USA
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Taipei Vet Gen Hosp, Dept Med Educ, Taipei, Taiwan
Natl Taiwan Univ, Inst Epidemiol & Prevent Med, Coll Publ Hlth, Taipei, Taiwan
Natl Yang Ming Chiao Tung Univ, Coll Med, Taipei, Taiwan
Minist Hlth & Welf, Bali Psychiat Ctr, New Taipei, TaiwanTaipei Vet Gen Hosp, Dept Med Educ, Taipei, Taiwan
Huang, Shiau-Shian
Yu, Yu-Hsiang
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Natl Yang Ming Chiao Tung Univ, Coll Med, Taipei, Taiwan
Taipei Vet Gen Hosp, Div Neurol, Taipei, TaiwanTaipei Vet Gen Hosp, Dept Med Educ, Taipei, Taiwan
Yu, Yu-Hsiang
Chen, His-Han
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Yang Ji Mental Hosp, Dept Psychiat, Keelung, TaiwanTaipei Vet Gen Hosp, Dept Med Educ, Taipei, Taiwan
Chen, His-Han
Hung, Chia-Chun
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机构:
Minist Hlth & Welf, Bali Psychiat Ctr, New Taipei, TaiwanTaipei Vet Gen Hosp, Dept Med Educ, Taipei, Taiwan
Hung, Chia-Chun
Wang, Yao-Ting
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机构:
Minist Hlth & Welf, Bali Psychiat Ctr, New Taipei, TaiwanTaipei Vet Gen Hosp, Dept Med Educ, Taipei, Taiwan
Wang, Yao-Ting
Chang, Chieh Hsin
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Minist Hlth & Welf, Bali Psychiat Ctr, New Taipei, TaiwanTaipei Vet Gen Hosp, Dept Med Educ, Taipei, Taiwan
Chang, Chieh Hsin
Peng, Syu-Jyun
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Taipei Med Univ, Coll Med, Program Artificial Intelligence Med, Taipei, TaiwanTaipei Vet Gen Hosp, Dept Med Educ, Taipei, Taiwan
Peng, Syu-Jyun
Kuo, Po-Hsiu
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Natl Taiwan Univ, Inst Epidemiol & Prevent Med, Coll Publ Hlth, Taipei, Taiwan
Natl Taiwan Univ Hosp, Dept Psychiat, Taipei, Taiwan
Taipei Med Univ, Wan Fang Hosp, Psychiat Res Ctr, Taipei, TaiwanTaipei Vet Gen Hosp, Dept Med Educ, Taipei, Taiwan