A combined effect of molecular electrostatic potential and N7 accessibility explains sequence-dependent binding of cis-[Pt(NH3)2(H2O)2]2+ to DNA duplexes

被引：0

作者：

Monjardet-Bas, V ^{[1
]}

Elizondo-Riojas, MA ^{[1
]}

Chottard, JC ^{[1
]}

Kozelka, J ^{[1
]}

机构：

[1] Univ Paris 05, Chim & Biochim Pharmacol & Toxicol Lab, CNRS, UMR 8601, F-75270 Paris, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2002年 / 41卷 / 16期

关键词：

D O I：

10.1002/1521-3773(20020816)41:16<2998::AID-ANIE2998>3.0.CO;2-1

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The main factor determining the sequence-selective binding of platinum complexes to DNA is the accessibility of the N7 atom of guanine (G). The rate constants observed for the reactions of cis-[Pt(NH3)2(H2O)2]2+ with DNA G residues in various sequences can be accounted for by a mathematical formula compatible with the kinetic model shown in the scheme, where the association constant K is determined by the molecular electrostatic potential and the rate constant k by the accessible area of the N7 van der Waals sphere.

引用

页码：2998 / 3001

页数：4

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