RNA granules: post-transcriptional and epigenetic modulators of gene expression

被引:666
|
作者
Anderson, Paul [1 ,2 ]
Kedersha, Nancy [1 ,2 ]
机构
[1] Brigham & Womens Hosp, Div Rheumatol Allergy & Immunol, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Boston, MA 02115 USA
基金
美国国家卫生研究院;
关键词
MATERNAL MESSENGER-RNAS; P-BODY FORMATION; MALE GERM-CELLS; STRESS GRANULES; PROCESSING BODIES; BINDING-PROTEIN; CHROMATOID BODY; TRANSLATIONAL REPRESSION; HEAT-SHOCK; MICRORNA;
D O I
10.1038/nrm2694
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The composition of cytoplasmic messenger ribonucleoproteins (mRNPs) is determined by their nuclear and cytoplasmic histories and reflects past functions and future fates. The protein components of selected mRNP complexes promote their assembly into microscopically visible cytoplasmic RNA granules, including stress granules, processing bodies and germ cell (or polar) granules. We propose that RNA granules can be both a cause and a consequence of altered mRNA translation, decay or editing. in this capacity, RNA granules serve as key modulators of post-transcriptional and epigenetic gene expression.
引用
收藏
页码:430 / 436
页数:7
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