Synthesis and structure-activity relationship study of diaryl[d, f][1,3]diazepines as potential anti-cancer agents

被引：13

作者：

Yan, Longjia ^{[1
,2
]}

Wang, Hui ^{[1
,2
]}

Chen, Yunpeng ^{[1
,2
]}

Li, Zhiwei ^{[1
,2
]}

Pei, Yazhong ^{[1
,2
]}

机构：

[1] Jilin Univ, Ctr Combinatorial Chem & Drug Discovery, Coll Chem, 1266 Fujin Rd, Changchun 130012, Jilin, Peoples R China

[2] Jilin Univ, Sch Pharmaceut Sci, 1266 Fujin Rd, Changchun 130012, Jilin, Peoples R China

来源：

MOLECULAR DIVERSITY | 2018年 / 22卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Benzo[1,3]diazepine; Diaryl[d, f][1,3]diazepine; Structure-activity relationship; Anti-cancer activity; KINASE INHIBITORS; DOPAMINE; ANTAGONIST; DISCOVERY; RECEPTORS; ECOPIPAM; DESIGN;

D O I：

10.1007/s11030-017-9805-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We herein report the synthesis, biological activity and preliminary structure-activity relationships of a series of diaryl[1,3]diazepines. These compounds were able to inhibit the proliferation of many cancer cell lines, such as HeLa, MCF-7, SGC7901 and A549. When HeLa cells were treated with lead compounds 7j and 7k at 3 concentration, cell arrest was observed in the G2/M phase. [GRAPHICS] .

引用

页码：323 / 333

页数：11

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