Activin-A drives the generation of human CD4+ICOS+IL-10-secreting regulatory T cells that suppress asthma in an aryl hydrocarbon receptor dependent pathway

被引：0
|
作者：
Tousa, S. [1 ]
Semitekolou, M. [1 ]
Morianos, I [1 ]
Trochoutsou, A., I [1 ]
Banos, A. [2 ]
Brodie, T. [3 ]
Kapasa, M. [2 ]
Poulos, N. [1 ]
Samitas, K. [4 ]
Paraskevopoulos, G. [5 ]
Gaga, M. [4 ]
Hawrylowicz, C. M. [6 ]
Sallusto, F. [3 ]
Xanthou, G. [1 ]
机构：
[1] Acad Athens BRFAA, Cellular Immunol Lab, Biomed Res Fdn, Athens, Greece
[2] Acad Athens BRFAA, Biomed Res Fdn, Athens, Greece
[3] Inst Res Biomed IRB, Bellinzona, Switzerland
[4] Athens Chest Hosp Sotiria, Athens, Greece
[5] 401 Gen Mil Hosp Athens, Athens, Greece
[6] Kings Coll London, London, England
来源：
ALLERGY | 2014年 / 69卷
基金：
英国医学研究理事会;
关键词：
D O I：
暂无
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
110
引用
收藏
页码：50 / 50
页数：1
相关论文
共 50 条
  • [1] Activin-A is a critical inducer of human CD4+ICOS+IL-10-secreting regulatory T cells that suppress allergen-driven T cell responses in vitroand experimental asthma in a humanized mouse model in vivo
    Tousa, Sofia
    Semitekolou, Maria
    Morianos, Ioannis
    Banos, Aggelos
    Trochoutsou, Aikaterini
    Brodie, Tess
    Poulos, Nikos
    Samitas, Konstantinos
    Kapasa, Maria
    Paraskevopoulos, Giannis
    Gaga, Mina
    Hawrylowicz, Catherine
    Sallusto, Federica
    Xanthou, Georgina
    EUROPEAN RESPIRATORY JOURNAL, 2015, 46
  • [2] Notch signaling drives IL-22 secretion in CD4+ T cells by stimulating the aryl hydrocarbon receptor
    Alam, Muhammad Shamsul
    Maekawa, Yoichi
    Kitamura, Akiko
    Tanigaki, Kenji
    Yoshimoto, Takayuki
    Kishihara, Kenji
    Yasutomo, Koji
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (13) : 5943 - 5948
  • [3] The effects of Aryl Hydrocarbon Receptor activation by TCDD on IL-12R signaling and generation of regulatory T cells
    Marshall, Nikki B.
    Kerkvliet, Nancy I.
    JOURNAL OF IMMUNOLOGY, 2009, 182
  • [4] IFN-γ Promotes Generation of IL-10 Secreting CD4+ T Cells that Suppress Generation of CD8 Responses in an Antigen-Experienced Host
    Liu, Xiao Song
    Leerberg, Joanne
    MacDonald, Kelli
    Leggatt, Graham R.
    Frazer, Ian H.
    JOURNAL OF IMMUNOLOGY, 2009, 183 (01): : 51 - 58
  • [5] Impaired IL-10-dependent Induction of Tolerogenic Dendritic Cells by CD4+CD25hiCD127lo/- Natural Regulatory T Cells in Human Allergic Asthma
    Nguyen, Khoa D.
    Vanichsarn, Christopher
    Nadeau, Kari C.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2009, 180 (09) : 823 - 833
  • [6] Aryl hydrocarbon receptor(AhR)-dependent CD8-like/cytotoxic reprogramming of CD4+ T cells
    Wang, H.
    Wei, Y.
    Garriga, D.
    Coulibaly, F.
    Yu, D.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2019, 49 : 364 - 364
  • [7] Aryl hydrocarbon receptor activity downstream of IL-10 signaling is required to promote regulatory functions in human dendritic cells
    Avancini, Daniele
    Testori, Alessandro
    Fresolone, Lucia
    Andolfi, Grazia
    Vuono, Michela
    Martinelli, Vittorio
    Sio, Francesca R. Santoni de
    Gregori, Silvia
    CELL REPORTS, 2023, 42 (03):
  • [8] Cytokine regulation in human CD4 T cells by the Aryl Hydrocarbon Receptor and GPR68
    McAleer, Jeremy P.
    Fan, Jun
    Roar, Bryanna
    Primerano, Donald A.
    Denvir, James
    JOURNAL OF IMMUNOLOGY, 2018, 200 (01):
  • [9] Adoptive transfer of IL-10-secreting CD4+CD49b+ regulatory T cells suppresses ongoing arthritis
    Charbonnier, Louis-Marie
    Han, Wanda G. H.
    Quentin, Julie
    Huizinga, Tom W. J.
    Zwerina, Jochen
    Toes, Rene E. M.
    Jorgensen, Christian
    Louis-Plence, Pascale
    JOURNAL OF AUTOIMMUNITY, 2010, 34 (04) : 390 - 399
  • [10] IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells
    Vieira, PL
    Christensen, JR
    Minaee, S
    O'Neill, EJ
    Barrat, FJ
    Boonstra, A
    Barthlott, T
    Stockinger, B
    Wraith, DC
    O'Garra, A
    JOURNAL OF IMMUNOLOGY, 2004, 172 (10): : 5986 - 5993
12345