Smooth and selective formation of the cyclic 1,N2-propano adducts in the reactions of guanine nucleosides and nucleotides with acetaldehyde

被引：11

作者：

Sako, M ^{[1
]}

Yaekura, I ^{[1
]}

Deyashiki, Y ^{[1
]}

机构：

[1] Gifu Pharmaceut Univ, Gifu 5028585, Japan

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 38期

关键词：

cyclic; 1; N-2-propano guanine adduct; guanine nucleosides and nucleotides; acetaldehyde;

D O I：

10.1016/S0040-4039(02)01530-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The treatment of guanine nucleosides and nucleotides with excess acetaldehyde in pH 8.0 phosphate buffer containing a basic amino acid such as arginine and lysine resulted in the smooth and selective formation of the corresponding cyclic 1,N-2-propano adducts even under mild conditions. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：6701 / 6703

页数：3

共 22 条

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