Is Lipoprotein(a) Ready for Prime-Time Use in the Clinic?

被引：12
|
作者：
Ellis, Katrina L. [1 ,2 ]
Watts, Gerald F. [1 ,3 ]
机构：
[1] Univ Western Australia, Sch Med, 35 Stirling Highway, Crawley, WA 6009, Australia
[2] Univ Western Australia, Sch Biomed Sci, 35 Stirling Highway, Crawley, WA 6009, Australia
[3] Royal Perth Hosp, Dept Cardiol, Lipid Disorders Clin, GPO Box X2213, Perth, WA 6001, Australia
来源：
CARDIOLOGY CLINICS | 2018年 / 36卷 / 02期
关键词：
Lipoprotein(a); Atherosclerotic cardiovascular disease; Pharmacotherapy; Risk assessment; Models of care; HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA; CARDIOVASCULAR-DISEASE; DOUBLE-BLIND; TARGETING APOLIPOPROTEIN(A); VASCULAR RISK; CORONARY; APHERESIS; DYSLIPIDEMIA; OUTCOMES; THERAPY;
D O I：
10.1016/j.ccl.2017.12.010
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Lipoprotein(a) is a low-density lipoprotein-like particle covalently bound to a glycoprotein called apolipoprotein(a) that is under potent genetic control. Plasma levels of lipoprotein(a) vary by up to 1000-fold among individuals, with 1 in 4 having levels that increase the risk of atherosclerotic cardiovascular disease. New evidence supports a causal role for lipoprotein(a) in atherosclerotic cardiovascular disease and aortic valve stenosis. Individuals with elevated lipoprotein(a) have a high life-time burden of atherosclerotic cardiovascular disease. This notion is important for coronary prevention. But is lipoprotein(a) ready for prime-time use in coronary prevention clinics?
引用
收藏
页码：287 / +
页数：13
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