Biorecognizable polymers: Design, structure, and bioactivity

被引：17
|
作者：
Kopecek, J [1 ]
Kopeckova, P [1 ]
Konak, C [1 ]
机构：
[1] UNIV UTAH,DEPT PHARMACEUT & PHARMACEUT CHEM,CCCD,SALT LAKE CITY,UT 84112
来源：
JOURNAL OF MACROMOLECULAR SCIENCE-PURE AND APPLIED CHEMISTRY | 1997年 / A34卷 / 10期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1080/10601329708010328
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
This paper provides a review of the relationship between the structure of biorecognizable N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers and their aggregation in solution with concomitant changes in biorecognition. To test the hypothesis that side-chain terminal moieties play a critical role in the association process, HPMA copolymers containing different stimuli sensitive hydrophobic moieties at side-chain termini (azobenzene, spiropyran, chlorin eg, and phthalocyanine) were synthesized, and their solution and biological properties evaluated. The results obtained are of importance for the design of polymeric drug carriers as well as for the design of supramolecular systems with specialized functions.
引用
收藏
页码：2103 / 2117
页数：15
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