Clinical features in different age groups of patients with autoimmune hepatitis

被引:26
|
作者
Peng, Milin [1 ]
Li, Yi [1 ]
Zhang, Min [1 ]
Jiang, Yongfang [1 ]
Xu, Yuan [1 ]
Tian, Yi [1 ]
Peng, Feng [1 ]
Gong, Guozhong [1 ]
机构
[1] Cent S Univ, Xiangya Hosp 2, Ctr Liver Dis, Changsha 410011, Hunan, Peoples R China
关键词
autoimmune hepatitis; clinical presentation; concurrent autoimmune diseases; China; RISK-FACTORS; TYPE-1; ANTIBODIES; OUTCOMES; DISEASE;
D O I
10.3892/etm.2013.1363
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The Chinese population are at an increased risk of autoimmune hepatitis (AIH). The aims of this study were to determine the demographic and clinical features of AIH in China. A total of 83 patients with AIH diagnosed by the revised scoring system were re-analyzed, and the clinical presentations among the different ages were compared. The patients were classified according to age at presentation. AIH occurred in patients aged 30 years (9.6%), 31-39 years (10.8%), 40-49 years (16.9%), 50-59 years (31.3%) and 60 years (31.3%). There were no differences in the form of the clinical presentation, concurrent autoimmune diseases, cirrhosis distribution and autoantibodies among the groups. However, patients aged 60 years presented with higher levels of alkaline phosphatase (ALP) and -glutamyl transpeptidase (-GT) compared with patients aged 30 years (P=0.034, P=0.043, respectively), and patients aged 31-39 years had a significantly lower immunoglobulin G (IgG) level compared with those aged 50-59 years (P=0.049) and those aged 60 years (P=0.012). By contrast, patients aged 30 years had a significantly higher total bilirubin (TBIL) level compared with those aged 31-39 years (P=0.007), 50-59 years (P=0.002) and 60 years (P=0.013). A substantial portion of patients with AIH were aged >60 years, indicating a poor liver-associated outcome under current management strategies. Elderly patients appeared to be more asymptomatic compared with the younger patients.
引用
收藏
页码:145 / 148
页数:4
相关论文
共 50 条
  • [1] Clinical features in different age groups of patients with diabetic ketoacidosis
    Zhang, Ying
    Li, Ping
    Chen, Ruoran
    Yang, Xin
    Liang, Linlang
    [J]. DIABETES-METABOLISM RESEARCH AND REVIEWS, 2014, 30 : 2 - 2
  • [2] The Clinical Features of Elderly Autoimmune Hepatitis Patients
    Hiramatsu, Naoki
    Matsumoto, Kengo
    Hosui, Atsushi
    [J]. HEPATOLOGY, 2018, 68 : 1125A - 1125A
  • [3] Clinical features of giardiasis in different age groups of pediatric in-patients
    Almirall, Pedro
    Alfonso, Maydel
    Avila, Ivonne
    Salazar, Yohana
    Escobedo, Angel A.
    Nunez, Fidel A.
    Cimerman, Sergio
    [J]. REVISTA CHILENA DE INFECTOLOGIA, 2013, 30 (05): : 502 - 506
  • [4] Clinical, immunological and morphological features in different types of autoimmune hepatitis
    Sandler, Yu G.
    Saliev, K. G.
    Backih, S. N.
    Khomeriki, S. G.
    Khaymenova, T. Yu
    Dorofeev, A. S.
    Sbikina, E. S.
    Vinnitskaya, E. V.
    [J]. TERAPEVTICHESKII ARKHIV, 2020, 92 (02): : 43 - 47
  • [5] Clinical and histologic features in patients with acute autoimmune hepatitis
    Kessler, WR
    Chalasani, N
    Cummings, OW
    Lumeng, L
    Eckert, G
    Kwo, PY
    [J]. GASTROENTEROLOGY, 2004, 126 (04) : A734 - A734
  • [6] Clinical features of elderly Chinese patients with autoimmune hepatitis
    Zhang, Ying
    Sun, Wan-Li
    Jin, De-Long
    Du Jing-Hua
    [J]. TURKISH JOURNAL OF GASTROENTEROLOGY, 2013, 24 (06): : 489 - 494
  • [7] Histologic and Clinical Features of Patients with Chronic Hepatitis C with Autoimmune Features
    Pai, R. K.
    Westerhoff, M.
    Jenkins, E.
    Te, H.
    Hart, J.
    [J]. LABORATORY INVESTIGATION, 2010, 90 : 367A - 367A
  • [8] Histologic and Clinical Features of Patients with Chronic Hepatitis C with Autoimmune Features
    Pai, R. K.
    Westerhoff, M.
    Jenkins, E.
    Te, H.
    Hart, J.
    [J]. MODERN PATHOLOGY, 2010, 23 : 367A - 367A
  • [9] Vestibular Neuritis in Patients Among Different Age Groups: Clinical Features and Outcomes
    Jacobson, Gary
    McCaslin, Devin
    [J]. JOURNAL OF THE AMERICAN ACADEMY OF AUDIOLOGY, 2020, 31 (09) : 627 - 627
  • [10] Clinical features of hepatocellular carcinoma in patients with autoimmune hepatitis in Japan
    Hiromasa Ohira
    Kazumichi Abe
    Atsushi Takahashi
    Mikio Zeniya
    Takafumi Ichida
    [J]. Journal of Gastroenterology, 2013, 48 : 109 - 114