Effect of nitroglycerine on content of second messengers in myocytes of rat thoracic aorta

被引：1
|
作者：
Dukhanin, A. S. [1 ]
Shimanovskii, N. L. [1 ]
机构：
[1] Russian State Med Univ, Moscow 117437, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2006年 / 141卷 / 05期
关键词：
calcium ions; cAMP; cGMP; nitrates; myocytes;
D O I：
10.1007/s10517-006-0228-7
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We evaluated the concentration dependence and time dependence of the effect of nitroglycerine on intracellular content of cAMP, cGMP, and free Ca2+. It was shown that after norepinephrine stimulation, nitroglycerine exhibited calcium-blocking activity in lower concentrations (starting from 10(-7) M). Under conditions of experimental nitrate tolerance the dose-dependent effect of nitroglycerine on intracellular cGMP and Ca2+ was less pronounced. Calcium-blocking activity of nitroglycerine decreased most significantly upon stimulation of myocytes with norepinephrine.
引用
收藏
页码：588 / 591
页数：4
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