FORMAL SYNTHESIS OF GEPHYROTOXIN 287C

被引：3
|
作者：
Takashima, Katsuki [1 ]
Toyooka, Naoki [1 ]
机构：
[1] Univ Toyama, Grad Sch Innovat Life Sci, 3190 Gofuku, Toyama 9308555, Japan
来源：
HETEROCYCLES | 2019年 / 99卷 / 01期
关键词：
ENANTIOSELECTIVE TOTAL-SYNTHESIS; NEOTROPICAL FROG; ALKALOIDS;
D O I：
10.3987/COM-18-S(F)25
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The enantioselective formal synthesis of (-)-gephyrotoxin 287C (1) has been achieved from octahydroquinolinone 8. The alpha, beta-unsaturated ester 16, whose enantiomer was a key intermediate for the total synthesis of (+)-1, was synthesized by highly stereoselective Michael-type conjugate addition reaction to 8 and subsequent transformations.
引用
收藏
页码：649 / 660
页数：12
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