Group II metabotropic glutamate receptors and schizophrenia

被引：49
|
作者：
Moreno, Jose L. [1 ,3 ]
Sealfon, Stuart C. [2 ,4 ]
Gonzalez-Maeso, Javier [1 ,2 ,3 ]
机构：
[1] Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA
[2] Mt Sinai Sch Med, Dept Neurol, New York, NY 10029 USA
[3] Mt Sinai Sch Med, Div Basic Neurosci, New York, NY 10029 USA
[4] Mt Sinai Sch Med, Ctr Translat Syst Biol, New York, NY 10029 USA
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 2009年 / 66卷 / 23期
关键词：
Schizophrenia; Antipsychotics; G protein-coupled receptors (GPCR); Serotonin receptors; 5-HT2A; Metabotropic glutamate receptors; mGluR2; mGluR3; PROTEIN-COUPLED RECEPTOR; TYPE-3 GENE GRM3; DORSOLATERAL PREFRONTAL CORTEX; CATECHOL-O-METHYLTRANSFERASE; ATYPICAL ANTIPSYCHOTICS; WORKING-MEMORY; OBSTETRIC COMPLICATIONS; ACTIVATION MECHANISM; MOLECULAR-MECHANISMS; HALLUCINOGENIC DRUG;
D O I：
10.1007/s00018-009-0130-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Schizophrenia is one of the most common mental illnesses, with hereditary and environmental factors important for its etiology. All antipsychotics have in common a high affinity for monoaminergic receptors. Whereas hallucinations and delusions usually respond to typical (haloperidol-like) and atypical (clozapine-like) monoaminergic antipsychotics, their efficacy in improving negative symptoms and cognitive deficits remains inadequate. In addition, devastating side effects are a common characteristic of monoaminergic antipsychotics. Recent biochemical, preclinical and clinical findings support group II metabotropic glutamate receptors (mGluR2 and mGluR3) as a new approach to treat schizophrenia. This paper reviews the status of general knowledge of mGluR2 and mGluR3 in the psychopharmacology, genetics and neuropathology of schizophrenia.
引用
收藏
页码：3777 / 3785
页数：9
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