Methylation of Histone H3K79 by Dot1L Requires Multiple Contacts with the Ubiquitinated Nucleosome

被引：9
|
作者：
Zhang, Yi [1 ]
Kutateladze, Tatiana G. [1 ]
机构：
[1] Univ Colorado, Sch Med, Dept Pharmacol, Aurora, CO 80045 USA
来源：
MOLECULAR CELL | 2019年 / 74卷 / 05期
关键词：
H2B;
D O I：
10.1016/j.molcel.2019.05.013
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cryo-EM structures of Dot1L in complex with a ubiquitinated nucleosome provide the long-sought-after molecular mechanism of Dot1L-mediated methylation of lysine 79 in histone H3 and explain crosstalk with histone H2B ubiquitination.
引用
收藏
页码：862 / 863
页数：2
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