MicroRNA-106a inhibits cell proliferation and induces apoptosis in colorectal cancer cells

被引：19

作者：

Huang, Qinghua ^{[1
]}

Ma, Qunying ^{[2
]}

机构：

[1] Guangxi Med Univ, Affiliated Tumor Hosp, Dept Breast Surg, Nanning 530021, Guangxi, Peoples R China

[2] Guangzhou Med Univ, Affiliated Hosp 5, Dept Gastroenterol, 621 Gangwan Rd, Guangzhou 510700, Guangdong, Peoples R China

来源：

ONCOLOGY LETTERS | 2018年 / 15卷 / 06期

基金：

美国国家卫生研究院;

关键词：

colorectal cancer; microRNA-106a; cell proliferation; apoptosis; MAMMALIAN MESSENGER-RNAS; COLON-CANCER; EXPRESSION; TARGETS; TUMORS;

D O I：

10.3892/ol.2018.8516

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNAs (miRNAs) regulate mammalian cell growth, differentiation and apoptosis by altering the expression of other genes, and serve multiple roles in tumorigenesis and progression. miR-106a has been implicated in several types of malignancies. However, its role in colorectal cancer (CRC) remains unknown. The present study reported that in this particular cancer, miR-106a exhibits a tumor suppressive role. It was demonstrated that the high expression of miR-106a in CRC cells is negatively associated with E2F transcription factor 1 protein level and positively associated with caspase activation, suggesting a potential molecular switch.

引用

页码：8941 / 8944

页数：4

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