The analysis of socio-environmental vulnerability is carried out through different approaches, using a broad range of data and techniques. In this context, this work deals with a synthetic index of vulnerability face the environmental conditionings of human leptospirosis in urban agglomeration of the Metropolitan Area of Curitiba. To do so, the technique of synthesis mapping was applied to assess social vulnerability and, in an integrated manner, mark the flooding areas, The results allowed to identify, within the possibilities and limits of the mapping, that the methodology is effective to represent the environmental vulnerahility to human leptospirosis, a fact proven by field work. Conditions of high and very-high social vulnerability are identified, in larger proportions, in the cities of the geographical peripheries of the agglomeration and in sociological peripheries, whereas the conditions of low and very-low vulnerability are associated with the central and most valued regions, concentrating on the city of Curitiba, It is noteworthy that this vulnerability indicator allows monitoring the spatial distribution of the social and environmental frailty conditions regarding a problem, and thus constitutes a proper assistance tool for the implementation of public policies aimed at the control and eradication of human leptospirosis.