Hedgehog signaling and radiation induced liver injury: a delicate balance

被引：9

作者：

Kabarriti, Rafi ^{[1
]}

Guha, Chandan ^{[1
,2
]}

机构：

[1] Albert Einstein Coll Med, Montefiore Med Ctr, Dept Radiat Oncol, Bronx, NY 10467 USA

[2] Albert Einstein Coll Med, Dept Pathol, Montefiore Med Ctr, Bronx, NY 10467 USA

来源：

HEPATOLOGY INTERNATIONAL | 2014年 / 8卷 / 03期

关键词：

Radiation-induced liver disease; Hedgehog signaling; HEPATOCELLULAR-CARCINOMA PATIENTS; GROWTH-FACTOR-BETA; VENOOCCLUSIVE DISEASE; ENDOTHELIAL-CELLS; ACTIVATION; PATHWAY; CANCER; TRANSPLANTATION; RADIOTHERAPY; OBSTRUCTION;

D O I：

10.1007/s12072-014-9532-x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Radiation-induced liver disease (RILD) is a major limitation of radiation therapy (RT) for the treatment of liver cancer. Emerging data indicate that hedgehog (Hh) signaling plays a central role in liver fibrosis and regeneration after liver injury. Here, we review the potential role of Hh signaling in RILD and propose the temporary use of Hh inhibition during liver RT to radiosensitize HCC tumor cells and inhibit their progression, while blocking the initiation of the radiation-induced fibrotic response in the surrounding normal liver.

引用

页码：316 / 320

页数：5

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