Simultaneous presentation of kappa-restricted chronic lymphocytic leukemia and lambda light chain AL amyloidosis

被引：5
|
作者：
von Keudell, Gottfried [1 ]
Sanchorawala, Vaishali [2 ,3 ]
O'Hara, Carl [2 ]
Seldin, David C. [2 ,3 ]
Sloan, J. Mark [2 ,3 ]
机构：
[1] Univ Chicago, Dept Hematol & Oncol, Chicago, IL 60637 USA
[2] Boston Univ, Sch Med, Boston, MA 02118 USA
[3] Amyloid Treatment & Res Program, Boston, MA USA
来源：
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS | 2014年 / 21卷 / 02期
关键词：
AL amyloidosis; CLL; plasma cell dyscrasia; NON-HODGKINS-LYMPHOMA; SYSTEMIC AMYLOIDOSIS;
D O I：
10.3109/13506129.2013.854205
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We report on a 58-year-old man who presented with simultaneous kappa-restricted chronic lymphocytic leukemia (CLL) and a lambda-restricted plasma cell dyscrasia causing AL amyloidosis involving the kidney and GI tract. While monoclonal immunoglobulins occasionally produced by CLL has previously been implicated in AL amyloidosis, this is the first case of AL amyloidosis resulting from a distinct plasma cell dyscrasia that is not clonally related to the concurrent CLL. Appropriate treatment depended on detailed pathologic diagnosis of both disease processes.
引用
收藏
页码：124 / 127
页数：4
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