Clean Synthesis of Pyrano[2,3-d]pyrimidine and Its Derivatives in Aqueous Media

被引：0

作者：

Li, Shenghui ^{[1
]}

Gao, Na ^{[1
]}

Li, Jitai ^{[1
]}

机构：

[1] Hebei Univ, Coll Chem & Environm Sci, Baoding 071002, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 29卷 / 03期

关键词：

pyrano[2,3-d]pyrimidine; benzyltrimethyl ammonium bromide; green synthesis; ONE-POT SYNTHESIS; ORGANIC-SYNTHESIS;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of pyrano[2,3-d]pyrimidine derivatives were synthesized by the reaction of aromatic aldehyde, malononitrile and 2-amino-4,6-dihydroxylpyrimidine in the presence of benzyltrimethyl ammonium bromide in water at 80 degrees C. The structures of the products were characterized by IR, H-1 NMR spectra and elemental analysis. Compared with other synthetic methods, this method has the advantages of neutral conditions, high yields and simple work-up procedures. In addition, water as a green solvent gave some merits such as cheapness, safty, and non-pollution.

引用

页码：466 / 469

页数：4

共 17 条

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