Concise total synthesis of (±)-pisiferin

被引：7
|
作者：
Li, Yulong
Li, Liqi
Guo, Yueming
Xie, Zhixiang [1 ]
机构：
[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China
来源：
TETRAHEDRON | 2015年 / 71卷 / 49期
基金：
中国国家自然科学基金; 高等学校博士学科点专项科研基金;
关键词：
Icetaxane-type diterpenes; Total synthesis; Pisiferin; Suzuki coupling; F-C alkylation; ICETEXANE DITERPENES; (+/-)-ISOPISIFERIN;
D O I：
10.1016/j.tet.2015.10.032
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A concise total synthesis of (+/-)-pisiferin has been accomplished from commercially available compounds alpha-cydocitral (9) and 4-bromo-2-isopropylphenol (10) via Suzuki coupling and F-C alkylation as key reaction in five steps with an overall yield of 22%. The feature of this concise synthesis is a convergent strategy coupled by Suzuki reaction. This work not only provides a strategy to approach the total synthesis of pisiferin itself but also serves as an additional correlation origin to which many related icetaxane-type diterpenes can be referred. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：9282 / 9286
页数：5
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