Serum methylation levels of TAC1, SEPT9 and EYA4 as diagnostic markers for early colorectal cancers: a pilot study

被引：29

作者：

Liu, Yanqun ^{[1
]}

Tham, Chee Klan ^{[2
]}

Ong, Simon Y. K. ^{[2
]}

Ho, Kok Sun ^{[1
]}

Lim, Jit Fong ^{[1
]}

Chew, Min Hoe ^{[1
]}

Lim, Che Kang ^{[3
]}

Zhao, Yi ^{[3
]}

Tang, Choong Leong ^{[1
]}

Eu, Kong Weng ^{[1
]}

机构：

[1] Singapore Gen Hosp, Dept Colorectal Surg, Singapore 169608, Singapore

[2] Natl Canc Ctr Singapore, Dept Med Oncol, Singapore, Singapore

[3] Singapore Gen Hosp, Dept Clin Res, Singapore 169608, Singapore

来源：

BIOMARKERS | 2013年 / 18卷 / 05期

基金：

英国医学研究理事会;

关键词：

Colorectal cancer; DNA methylation; early diagnosis; sensitivity and specificity; serum; FECAL OCCULT BLOOD; CELL-FREE DNA; PROMOTER METHYLATION; ABERRANT METHYLATION; MULTIPLE GENES; PLASMA; SAMPLES; BIOMARKERS; HYPERMETHYLATION; POPULATION;

D O I：

10.3109/1354750X.2013.798745

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Objective: To identify methylated genes in serum with diagnostic potentials for early colorectal cancer (CRC). Methods: Serum methylation levels of up to 12 genes were measured in two sets of serum samples with the second set from 26 stage I CRC patients and 26 age/gender-matched controls. Results: Serum methylation levels of TAC1, SEPT9, and EYA4 were significant discriminants between stage I CRC and healthy controls. Combination of TAC1 and SEPT9 rendered 73.1% sensitivity with 92.3% specificity. Conclusion: Serum methylation levels of TAC1, SEPT9 and EYA4 may be useful biomarkers for early detection of CRC though a validation study is necessary.

引用

页码：399 / 405

页数：7

共 4 条

[1] Postoperative Serum Methylation Levels of TAC1 and SEPT9 Are Independent Predictors of Recurrence and Survival of Patients with Colorectal Cancer
Tham, CheeKian
Chew, MinHoe
Soong, Richie
Lim, JitFong
Ang, MeiKim
Tang, ChoongLeong
Zhao, Yi
Ong, Simon Y. K.
Liu, Yanqun
CANCER, 2014, 120 (20) : 3131 - 3141
[2] Aberrant methylation scanning by quantitative DNA melting analysis with hybridization probes as exemplified by liquid biopsy of SEPT9 and HIST1H4F in colorectal cancer
V. Botezatu, Irina
Kondratova, Valentina N.
Stroganova, Anna M.
Dranko, Svetlana L.
V. Lichtenstein, Anatoly
CLINICA CHIMICA ACTA, 2023, 551
[3] SEPT9, H4C6, and RASSF1A methylation in nasopharyngeal swabs: A reflection of potential minimally invasive biomarkers for early screening of nasopharyngeal cancer
Qian, Tai
Zhou, Zhiwei
Zhang, Qiongxia
Liou, Yu-Light
Zhou, Honghao
MEDICINE, 2023, 102 (50) : E36583
[4] Clinical significance and diagnostic capacity of serum TK1, CEA, CA 19-9 and CA 72-4 levels in gastric and colorectal cancer patients
Ning, Shufang
Wei, Wene
Li, Jilin
Hou, Bingbing
Zhong, Jianhong
Xie, Yuxuan
Liu, Haizhou
Mo, Xianwei
Chen, Jiansi
Zhang, Litu
JOURNAL OF CANCER, 2018, 9 (03): : 494 - 501

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