Chinese Guideline on Allergen Immunotherapy for Allergic Rhinitis: The 2022 Update

被引：19

作者：

Wang, Chengshuo ^{[1
,2
,3
,4
,5
]}

Bao, Yixiao ^{[6
]}

Chen, Jianjun ^{[7
]}

Chen, Xiaoyang ^{[8
]}

Cheng, Lei ^{[9
,10
]}

Guo, Yin Shi ^{[11
]}

Hao, Chuangli ^{[12
]}

Lai, He ^{[13
]}

Li, Huabin ^{[14
]}

Li, Jing ^{[15
]}

Liu, Changshan ^{[16
]}

Liu, Yun ^{[17
]}

Liu, Zheng ^{[18
]}

Lou, Hongfei ^{[1
,4
]}

Lv, Wei ^{[19
]}

Nong, Guangmin ^{[20
]}

Qiu, Qianhui ^{[21
]}

Ren, Xiumin ^{[22
]}

Shao, Jie ^{[23
]}

Shen, Yi-Hong ^{[24
]}

Shi, Li ^{[25
]}

Song, Xi-Cheng ^{[26
]}

Song, Yuxin ^{[27
]}

Tang, Suping ^{[28
]}

Wang, Hongtian ^{[29
]}

Wang, Xiangdong ^{[1
,2
,3
]}

Wang, Xueyan ^{[29
]}

Wang, Zhenlin ^{[30
]}

Wei, Qingyu ^{[31
]}

Xie, Hua ^{[32
]}

Xing, Zhimin ^{[33
]}

Xu, Rui ^{[34
]}

Xu, Yu ^{[35
]}

Yang, Qintai ^{[36
]}

Yao, Hongmei ^{[37
]}

Ye, Jing ^{[38
]}

You, Yiwen ^{[39
]}

Yu, Hongmeng ^{[14
]}

Yu, Yongmei ^{[40
]}

Zhang, Huanping ^{[41
]}

Zhang, Gehua ^{[36
]}

Zhang, Yuan ^{[5
]}

Zhi, Yuxiang ^{[42
]}

Zhou, Weikang ^{[43
]}

Zhu, Li ^{[44
]}

Zhu, Xinhua ^{[45
]}

Chai, Ruonan ^{[32
]}

Chen, Dehua ^{[34
]}

Guan, Kai ^{[42
]}

Huang, Zizhen ^{[36
]}

机构：

[1] Capital Med Univ, Beijing TongRen Hosp, Dept Otolaryngol Head & Neck Surg, Beijing, Peoples R China

[2] Beijing Inst Otorhinolaryngol, Beijing Key Lab Nasal Dis, Beijing, Peoples R China

[3] Beijing Inst Otorhinolaryngol, Beijing Lab Allerg Dis, Beijing, Peoples R China

[4] Chinese Acad Med Sci, Res Unit Diag & Treatment Chron Nasal Dis, Beijing, Peoples R China

[5] Capital Med Univ, Beijing TongRen Hosp, Dept Allergy, Beijing, Peoples R China

[6] Shanghai Tonxin Clin, Shanghai, Peoples R China

[7] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Otorhinolaryngol, Wuhan, Peoples R China

[8] Fujian Med Univ, Resp Med Ctr Fujian Prov, Dept Pulm & Crit Care Med, Affiliated Hosp 2, Quanzhou, Fujian, Peoples R China

[9] Nanjing Med Univ, Affiliated Hosp 1, Dept Otorhinolaryngol, Nanjing, Peoples R China

[10] Nanjing Med Univ, Affiliated Hosp 1, Clin Allergy Ctr, Nanjing, Peoples R China

[11] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Allergy & Immunol, Shanghai, Peoples R China

[12] Soochow Univ, Dept Resp Dis, Childrens Hosp, Suzhou, Peoples R China

[13] Guangzhou Med Univ, Dept Allergy, Affiliated Hosp 2, Guangzhou, Peoples R China

[14] Fudan Univ, Eye & ENT Hosp, Dept Otolaryngol, Shanghai, Peoples R China

[15] Guangzhou Med Univ, Dept Allergy & Clin Immunol, Affiliated Hosp 1, Guangzhou, Peoples R China

[16] Tianjin Med Univ, Dept Pediat, Hosp 2, Tianjin, Peoples R China

[17] Xi An Jiao Tong Univ, Dept Resp & Crit Care Med, Affiliated Hosp 2, Xian, Peoples R China

[18] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Otolaryngol Head & Neck Surg, Wuhan, Peoples R China

[19] Peking Union Med Coll Hosp, Dept Otorhinolaryngol, Beijing, Peoples R China

[20] Guangxi Med Univ, Dept Pediat, Affiliated Hosp 1, Nanning, Peoples R China

[21] Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Dept Otolaryngol Head & Neck Surg, Guangzhou, Peoples R China

[22] Hebei Med Univ, Dept Otorhinolaryngol Head & Neck Surg, Hosp 2, Shijiazhuang, Hebei, Peoples R China

[23] Shanghai Jiao Tong Univ, Dept Pediat, Ruijin Hosp, Sch Med, Shanghai, Peoples R China

[24] Zhejiang Univ, Coll Med, Dept Resp Dis, Affiliated Hosp 1, Hangzhou, Peoples R China

[25] Shandong Univ, Dept Otolaryngol, Hosp 2, Jinan, Peoples R China

[26] Qingdao Univ, Dept Otorhinolaryngol Head & Neck Surg, Yuhuangding Hosp, Yantai, Peoples R China

[27] Harbin Childrens Hosp, Dept Allergy, Harbin, Peoples R China

[28] Fujian Med Univ, Dept Allergy, Fuzhou Childrens Hosp, Fuzhou, Peoples R China

[29] Capital Med Univ, Beijing ShiJiTan Hosp, Dept Allergy, Beijing, Peoples R China

[30] Capital Med Univ, Xuanwu Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing, Peoples R China

[31] China Med Univ, Dept Allergy, Shengjing Hosp, Shenyang, Liaoning, Peoples R China

[32] Northern Theatre Gen Hosp, Dept Allergy, Shenyang, Liaoning, Peoples R China

[33] Peking Univ Peoples Hosp, Dept Otolaryngol Head & Neck Surg, Beijing, Peoples R China

[34] Sun Yat Sen Univ, Dept Allergy Otorhinolaryngol Hosp, Affiliated Hosp 1, Guangzhou, Peoples R China

[35] Wuhan Univ, Dept Otorhinolaryngol Head & Neck Surg, Renmin Hosp, Wuhan, Peoples R China

[36] Sun Yat Sen Univ, Dept Otolaryngol Head & Neck Surg, Affiliated Hosp 3, Guangzhou, Peoples R China

[37] Guizhou Prov Peoples Hosp, Dept Resp & Crit Care Med, Guiyang, Peoples R China

[38] Nanchang Univ, Dept Otorhinolaryngol Head & Neck Surg, Affiliated Hosp 1, Nanchang, Jiangxi, Peoples R China

[39] Nantong Univ, Dept Otolaryngol Head & Neck Surg, Affiliated Hosp, Nantong, Peoples R China

[40] Kunming Med Univ, Dept Otorhinolaryngol, Affiliated Hosp 1, Kunming, Yunnan, Peoples R China

[41] Shanxi Med Univ, Hosp 3, Tongji Shanxi Hosp, Shanxi Acad Med Sci,Dept Allergy,Shanxi Bethune H, Taiyuan, Peoples R China

[42] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Allergy, Beijing, Peoples R China

[43] Chongqing Gen Hosp, Dept Allergy, Chongqing, Peoples R China

[44] Peking Univ, Dept Otorhinolaryngol, Hosp 3, Beijing, Peoples R China

[45] Nanchang Univ, Dept Otorhinolaryngol Head & Neck Surg, Affiliated Hosp 2, Nanchang, Jiangxi, Peoples R China

[46] Harbin Med Univ, Dept Allergy, Affiliated Hosp 2, Harbin, Peoples R China

来源：

ALLERGY ASTHMA & IMMUNOLOGY RESEARCH | 2022年 / 14卷 / 06期

关键词：

Allergen immunotherapy; allergic rhinitis; guidelines; China; immunoglobulin E; biomarkers; rush immunotherapy; house dust mites; subcutaneous immunotherapy; HOUSE-DUST-MITE; LONG-TERM EFFICACY; AIR-POLLUTION EXPOSURE; SKIN-TEST REACTIVITY; SUBCUTANEOUS IMMUNOTHERAPY; SYSTEMIC REACTIONS; INTRALYMPHATIC IMMUNOTHERAPY; SUBLINGUAL IMMUNOTHERAPY; DERMATOPHAGOIDES-FARINAE; RUSH IMMUNOTHERAPY;

D O I：

10.4168/aair.2022.14.6.604

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

In the last few decades, there has been a progressive increase in the prevalence of allergic rhinitis (AR) in China, where it now affects approximately 250 million people. AR prevention and treatment include allergen avoidance, pharmacotherapy, allergen immunotherapy (AIT), and patient education, among which AIT is the only curative intervention. AIT targets the disease etiology and may potentially modify the immune system as well as induce allergen -specific immune tolerance in patients with AR. In 2017, a team of experts from the Chinese Society of Allergy (CSA) and the Chinese Allergic Rhinitis Collaborative Research Group (C2AR2G) produced the first English version of Chinese AIT guidelines for AR. Since then, there has been considerable progress in basic research of and clinical practice for AIT, especially regarding the role of follicular regulatory T (TFR) cells in the pathogenesis of AR and the use of allergen-specific immunoglobulin E (sIgE) in nasal secretions for the diagnosis of AR. Additionally, potential biomarkers, including TFR cells, sIgG4, and sIgE, have been used to monitor the incidence and progression of AR. Moreover, there has been a novel understanding of AIT during the coronavirus disease 2019 pandemic. Hence, there was an urgent need to update the AIT guideline for AR by a team of experts from CSA and C2AR2G. This document aims to serve as professional reference material on AIT for AR treatment in China, thus improving the development of AIT across the world.

引用

页码：604 / 652

页数：49

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