Targeting the Transforming Growth Factor-β Signaling in Cancer Therapy

被引：89
|
作者：
Sheen, Yhun Yhong [1 ]
Kim, Min-Jin [1 ]
Park, Sang-A [1 ]
Park, So-Yeon [1 ]
Nam, Jeong-Seok [2 ]
机构：
[1] Ewha Womans Univ, Coll Pharm, Seoul 120750, South Korea
[2] Gachon Univ, Lee Gil Ya Canc & Diabet Inst, Lab Tumor Suppressor, Inchon 406840, South Korea
来源：
BIOMOLECULES & THERAPEUTICS | 2013年 / 21卷 / 05期
关键词：
Transforming growth factor-beta (TGF-beta); EW-7197; ALK5; Breast cancer; Metastasis; EPITHELIAL-MESENCHYMAL TRANSITION; II RECEPTOR GENE; TGF-BETA; KINASE INHIBITOR; CARCINOMA CELLS; BONE METASTASIS; IN-VITRO; MUTATIONS; ANTAGONIST; EXPRESSION;
D O I：
10.4062/biomolther.2013.072
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
TGF-beta pathway is being extensively evaluated as a potential therapeutic target. The transforming growth factor-beta (TGF-beta) signaling pathway has the dual role in both tumor suppression and tumor promotion. To design cancer therapeutics successfully, it is important to understand TGF-beta related functional contexts. This review discusses the molecular mechanism of the TGF-beta pathway and describes the different ways of tumor suppression and promotion by TGF-beta. In the last part of the review, the data on targeting TGF-beta pathway for cancer treatment is assessed. The TGF-beta inhibitors in pre-clinical studies, and Phase I and II clinical trials are updated.
引用
收藏
页码：323 / 331
页数：9
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