The ketamine model for schizophrenia

被引：2
|
作者：
Alpert, M [1 ]
Angrist, B [1 ]
机构：
[1] NYU, Sch Med, Dept Psychiat, New York, NY 10016 USA
来源：
BEHAVIORAL AND BRAIN SCIENCES | 2003年 / 26卷 / 01期
关键词：
D O I：
10.1017/S0140525X03220021
中图分类号：
B84 [心理学];
学科分类号：
04 ; 0402 ;
摘要：
This commentary compares clinical aspects of ketamine with the amphetamine model of schizophrenia. Hallucinations and loss of insight, associated with amphetamine, seem more schizophrenia-like. Flat affect encountered with ketamine is closer to the clinical presentation in schizophrenia. We argue that flat affect is not a sign of schizophrenia, but rather, a risk factor for chronic schizophrenia.
引用
收藏
页码：82 / +
页数：15
相关论文
共 50 条
  • [1] Reviewing the ketamine model for schizophrenia
    Frohlich, Joel
    Van Horn, John D.
    [J]. JOURNAL OF PSYCHOPHARMACOLOGY, 2014, 28 (04) : 287 - 302
  • [2] KETAMINE AS A MODEL FOR SCHIZOPHRENIA DEFICITS
    Neill, Erica
    Rossell, Susan L.
    Morgan, Celia J. A.
    Carter, Olivia
    Joshua, Nicole
    [J]. SCHIZOPHRENIA RESEARCH, 2014, 153 : S275 - S275
  • [3] KETAMINE AS A MODEL OF SEMANTIC DEFICITS IN SCHIZOPHRENIA
    Neill, Erica
    Rossell, Susan
    [J]. SCHIZOPHRENIA RESEARCH, 2010, 117 (2-3) : 328 - 329
  • [4] Using Ketamine to Model Semantic Deficits in Schizophrenia
    Neill, Erica
    Rossell, Susan L.
    McDonald, Sarah
    Joshua, Nicole
    Jansen, Nicholas
    Morgan, Celia J. A.
    [J]. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2011, 31 (06) : 690 - 697
  • [5] Increased neurogenesis in a rat ketamine model of schizophrenia
    Keilhoff, G
    Bernstein, HG
    Becker, A
    Grecksch, G
    Wolf, G
    [J]. BIOLOGICAL PSYCHIATRY, 2004, 56 (05) : 317 - 322
  • [6] EXTRACELLULAR MATRIX ALTERATIONS IN THE KETAMINE MODEL OF SCHIZOPHRENIA
    Matuszko, Gabriela
    Curreli, Sebastiano
    Kaushik, Rahul
    Becker, Axel
    Dityatev, Alexander
    [J]. NEUROSCIENCE, 2017, 350 : 13 - 22
  • [7] The effect of Ketamine: Gunn rat as a Schizophrenia animal model
    Hayashida, Maiko
    Araki, Tomoko
    Hashioka, Sadayuki
    Horiguchi, Jun
    Kawano, Kiminori
    Miura, Syoko
    Miyaoka, Tsuyoshi
    Nagahama, Michiaru
    Tsuchie, Keiko
    Wake, Rei
    [J]. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2016, 19 : 181 - 182
  • [8] Impaired Hippocampal Oscillations in the Chronic Ketamine Model of Schizophrenia
    Kocsis, Bernat
    Kittelberger, Kara A.
    Hur, Elizabeth E.
    [J]. BIOLOGICAL PSYCHIATRY, 2009, 65 (08) : 53S - 53S
  • [9] USE OF FOLATE TO PREVENT SCHIZOPHRENIA IN ANIMAL MODEL OF KETAMINE INDUCE SCHIZOPHRENIA IN RATS
    Pereira, Flavio Augusto
    Damazio, Felipe
    Yugno, Alexandra
    [J]. SCHIZOPHRENIA RESEARCH, 2014, 153 : S194 - S194
  • [10] Famotidine Improved Schizophrenia-Like Behaviors in Acute Ketamine Model of Schizophrenia in Rats
    Unal, Gokhan
    Aricioglu, Feyza
    [J]. PSYCHIATRY AND BEHAVIORAL SCIENCES, 2020, 10 (02): : 45 - 54
12345