Netrin-4 derived from murine vascular endothelial cells inhibits osteoclast differentiation in vitro and prevents bone loss in vivo

被引：31

作者：

Enoki, Yuichiro ^{[1
]}

Sato, Tsuyoshi ^{[1
]}

Tanaka, Shinya ^{[2
]}

Iwata, Takanori ^{[8
]}

Usui, Michihiko ^{[6
]}

Takeda, Shu ^{[5
]}

Kokabu, Shoichiro ^{[1
]}

Matsumoto, Masahito ^{[4
]}

Okubo, Masahiko ^{[1
,4
]}

Nakashima, Keisuke ^{[6
]}

Yamato, Masayuki ^{[8
]}

Okano, Teruo ^{[8
]}

Fukuda, Toru ^{[5
]}

Chida, Dai ^{[1
]}

Imai, Yuuki ^{[9
]}

Yasuda, Hisataka ^{[10
]}

Nishihara, Tatsuji ^{[7
]}

Akita, Masumi ^{[3
]}

Oda, Hiromi ^{[2
]}

Okazaki, Yasushi ^{[4
]}

Suda, Tatsuo ^{[4
]}

Yoda, Tetsuya ^{[1
]}

机构：

[1] Saitama Med Univ, Dept Oral & Maxillofacial Surg, Saitama, Japan

[2] Saitama Med Univ, Dept Orthoped Surg, Saitama, Japan

[3] Saitama Med Univ, Div Morphol Sci, Saitama, Japan

[4] Saitama Med Univ, Res Ctr Genom Med, Div Funct Genom & Syst Med, Saitama, Japan

[5] Tokyo Med & Dent Univ, Dept Physiol & Cell Biol, Tokyo, Japan

[6] Kyushu Dent Univ, Dept Periodontol, Fukuoka, Japan

[7] Kyushu Dent Univ, Div Infect & Mol Biol, Fukuoka, Japan

[8] Tokyo Womens Med Univ, Inst Adv Biomed Engn & Sci, Tokyo, Japan

[9] Ehime Univ, Proteosci Ctr, Div Integrat Pathophysiol, Matsuyama, Ehime 790, Japan

[10] Oriental Yeast Co Ltd, Bioind Div, Planning & Dev, Tokyo, Japan

来源：

FEBS LETTERS | 2014年 / 588卷 / 14期

关键词：

Osteoclast; Netrin-4; Inhibition; Vascular endothelial cell; EXPRESSION; IDENTIFICATION; ANGIOGENESIS; PRECURSORS; RESORPTION; RECEPTORS;

D O I：

10.1016/j.febslet.2014.05.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bone is a highly vascularized organ, thus angiogenesis is a vital process during bone remodeling. However, the role of vascular systems in bone remodeling is not well recognized. Here we show that netrin-4 inhibits osteoclast differentiation in vitro and in vivo. Co-cultures of bone marrow macrophages with vascular endothelial cells markedly inhibited osteodast differentiation. Adding a neutralizing antibody, or RNA interference against netrin-4, restored in vitro osteoclast differentiation. Administration of netrin-4 prevented bone loss in an osteoporosis mouse model by decreasing the osteoclast number. We propose that vascular endothelial cells interact with bone in suppressing bone through netrin-4. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2262 / 2269

页数：8

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