A novel atom-economic synthesis of functionalized imidazolidines through copper(I)-catalyzed domino three-component coupling and cyclization reactions

被引：12

作者：

Li, Yufeng ^{[1
]}

Wu, Zhengguang ^{[1
]}

Shi, Jie ^{[1
]}

Bu, Hongzhong ^{[1
]}

Gu, Jiachao ^{[1
]}

Pan, Yi ^{[2
]}

机构：

[1] Nanjing Tech Univ, Coll Sci, Nanjing 211816, Jiangsu, Peoples R China

[2] Nanjing Univ, Sch Chem & Chem Engn, Nanjing 210093, Jiangsu, Peoples R China

来源：

TETRAHEDRON | 2014年 / 70卷 / 19期

关键词：

Alkynes; Cyclization; Imines; Multicomponent reactions; Nitrogen heterocycles; N-HETEROCYCLIC CARBENES; MULTICOMPONENT REACTIONS; NITROGEN-HETEROCYCLES; ENANTIOSELECTIVE SYNTHESIS; DERIVATIVES; RING; ALKYNES; IMINES; 2-PYRIDINECARBOXALDEHYDE; PROPARGYLAMINES;

D O I：

10.1016/j.tet.2014.03.063

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An interesting approach to functionalized imidazolidines is described. These compounds are obtained in a copper(l)-catalyzed domino three-component coupling and cyclization reaction involving two formaldehyde-derived imine units and a terminal alkyne. Alternatively, imidazolidines can be obtained from propargylamines and formaldehyde-derived imines. This strategy provides a straightforward and atom-economic pathway to construct imidazolidines with high yields and benefits from readily available starting materials, convenient one-pot operations. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：3134 / 3140

页数：7

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