Maternal serum concentration of soluble fms-like tyrosine kinase 1 and vascular endothelial growth factor in women with abnormal uterine artery Doppler and in those with fetal growth restriction

被引:79
|
作者
Savvidou, Makrina D.
Yu, Christina K.
Harland, Lisa C.
Hingorani, Aroon D.
Nicolaides, Kypros H.
机构
[1] Kings Coll Hosp London, Harris Birthright Res Ctr Fetal Med, London SE5 8RS, England
[2] UCL, Ctr Clin Pharmacol, Rayne Inst, London, England
关键词
soluble fms-like tyrosine kinase 1; vascular endothelial growth factor; preeclampsia; fetal growth restriction; uterine artery Doppler;
D O I
10.1016/j.ajog.2006.03.065
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: This study was undertaken to determine whether maternal serum concentration of the angiogenic factor vascular endothelial growth factor (VEGF) and its circulating antagonist, soluble fms-like tyrosine kinase 1 (sFlt-1), which have been implicated in the pathogenesis of preeclampsia (PE), are altered in pregnancies that subsequently develop PE and in those with established fetal growth restriction (FGR). Study design: Three groups of healthy pregnant women at 23 to 25 weeks of gestation were examined: group A (n = 42) with normal uterine artery Doppler waveforms, group B (n = 49) with abnormal uterine artery Doppler waveforms, and group C (n = 15) with abnormal Doppler results and established FGR. Comparisons between multiple groups were performed by using 1-way analysis of variance or Kruskal-Wallis test. Results: In group C, compared with group A, the median sFlt-1 was significantly higher (P < .0001) and VEGF was lower (P < .001). Group C included 3 women who had PE develop. In group B, 19 women had a normal outcome, 13 had PE develop, and 17 had FGR develop. There were no significant differences in sFlt-1 levels between any of the subgroups of group B and group A. Conclusion: Maternal serum concentration of sFlt-1 in pregnancies with FGR is increased but this increase is not evident in pregnancies with impaired placentation that subsequently had either FGR or PE develop. (c) 2006 Mosby, Inc. All rights reserved.
引用
收藏
页码:1668 / 1673
页数:6
相关论文
共 50 条
  • [1] First-trimester serum soluble fms-like tyrosine kinase-1, free vascular endothelial growth factor, placental growth factor and uterine artery Doppler in preeclampsia
    A O Odibo
    C C Rada
    A G Cahill
    K R Goetzinger
    M G Tuuli
    L Odibo
    G A Macones
    S K England
    Journal of Perinatology, 2013, 33 : 670 - 674
  • [2] First-trimester serum soluble fms-like tyrosine kinase-1, free vascular endothelial growth factor, placental growth factor and uterine artery Doppler in preeclampsia
    Odibo, A. O.
    Rada, C. C.
    Cahill, A. G.
    Goetzinger, K. R.
    Tuuli, M. G.
    Odibo, L.
    Macones, G. A.
    England, S. K.
    JOURNAL OF PERINATOLOGY, 2013, 33 (09) : 670 - 674
  • [3] Vascular Endothelial Growth Factor, Soluble Fms-Like Tyrosine Kinase 1, and the Severity of Coronary Artery Disease
    Kim, Soo-Young
    Lee, Sang-Hak
    Park, Sungha
    Kang, Seok-Min
    Chung, Namsik
    Shim, Won-Heum
    Cho, Seung-Yun
    Jee, Sun Ha
    Manabe, Ichiro
    Jang, Yangsoo
    ANGIOLOGY, 2011, 62 (02) : 176 - 183
  • [4] Vascular Endothelial Growth Factor and Soluble FMS-Like Tyrosine Kinase 1 in Hypertension in Pregnancy
    Karthikeyan, Vellore J.
    Jessani, Shahirose
    Balakrishnan, Balu
    Lane, Deirdre A.
    Baghdadi, Sabah
    Beevers, D. Gareth
    Lip, Gregory Y. H.
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2009, 53 (10) : A458 - A458
  • [5] Relationships of serum placental growth factor and soluble fms-like tyrosine kinase-1 with fetal and uterine artery Doppler indices in pre-eclampsia
    Li, Jingyu
    Cai, Ailu
    Yuan, Qian
    Ding, Hao
    Zhao, Dan
    INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, 2019, 145 (02) : 176 - 181
  • [6] Intrauterine growth restriction: the role of vascular endothelial growth factor and soluble FMS-like tyrosine kinase-1 in its pathogenesis
    Sri, S.
    Respati, Hari S.
    Soetrisno
    Nirwanasari, R.
    BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2015, 122 : 224 - 224
  • [7] Maternal serum placental growth factor and soluble fms-like tyrosine kinase 1 as early predictors of preeclampsia
    Shokry, Mahmoud
    Bedaiwy, Mohamed A.
    Fathalla, Mohamed M. F.
    Alsemary, Ali
    Elwakil, Sahar
    Murphy, Aisling
    ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 2010, 89 (01) : 143 - 146
  • [8] THE FMS-LIKE TYROSINE KINASE, A RECEPTOR FOR VASCULAR ENDOTHELIAL GROWTH-FACTOR
    DEVRIES, C
    ESCOBEDO, JA
    UENO, H
    HOUCK, K
    FERRARA, N
    WILLIAMS, LT
    SCIENCE, 1992, 255 (5047) : 989 - 991
  • [9] Characterization of the Soluble fms-Like Tyrosine Kinase-1 to Placental Growth Factor Ratio in Pregnancies Complicated by Fetal Growth Restriction
    Herraiz, Ignacio
    Droege, Lisa Antonia
    Gomez-Montes, Enery
    Henrich, Wolfgang
    Galindo, Alberto
    Verlohren, Stefan
    OBSTETRICS AND GYNECOLOGY, 2014, 124 (02): : 265 - 273
  • [10] Stability of Placental Growth Factor, soluble fms-like tyrosine kinase 1 and soluble fms-like tyrosine kinase 1 e15a in human serum and plasma
    Rowson, S.
    Reddy, M.
    Rolnik, D.
    Da Silva Costa, F.
    Palmer, K.
    AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY, 2019, 59 : 8 - 9