Genetic aspects of scrapie in sheep

被引：0
|
作者：
Piestrzynska-Kajtoch, Agata [1 ]
Rejduch, Barbara [1 ]
机构：
[1] Inst Zootech, Dzial Immuno & Cytogenet Zwierzat, PL-32083 Balica, Poland
来源：
MEDYCYNA WETERYNARYJNA-VETERINARY MEDICINE-SCIENCE AND PRACTICE | 2006年 / 62卷 / 12期
关键词：
PrP gene; scrapie;
D O I：
暂无
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Scrapie is a fatal, neurodegenerative disease occurring in sheep, goats and mufflons. It is commonly believed that its infectious agent is a protease-resistant form of host-encoded prion protein (PrP). Polymorphism of the coding region of PrP genes has been analyzed in many countries. Polymorphism of codons 136, 154 and 171 has been associated with outbreaks of scrapie. Valine (V) in codon 136, arginine (R) in codon 154, glutamine(Q) and histidine (H) in codon 171 are associated with susceptibility to scrapie while histidine (H) in codon 154 and arginine (R) in codon 171 are associated with resistance to the illness. Alanine (A) in codon 136 is associated with low susceptibility to scrapie.
引用
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页码：1344 / 1347
页数：4
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