Combination of a customized robotic system with a TLC scanner for high-throughput reaction screening

被引：8

作者：

Dinter, C ^{[1
]}

Weinmann, H ^{[1
]}

Merten, C ^{[1
]}

Schütz, A ^{[1
]}

Blume, T ^{[1
]}

Sander, M ^{[1
]}

Harre, M ^{[1
]}

Neh, H ^{[1
]}

机构：

[1] Schering AG, Proc Res, Automated Proc Optimizat, D-13342 Berlin, Germany

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2004年 / 8卷 / 03期

关键词：

D O I：

10.1021/op0341972

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Combination of a new and highly efficient robotic system for high-throughput reaction screening with a thin-layer chromatography (TLC) scanner is described. The system consists of a parallel synthesis robot capable of performing up to several hundred reactions in parallel and a second robot for analytical sample workup, dilution, and TLC-spotting. The automatically prepared TLC plates are analyzed with a modern TLC scanner which gives rapidly semi-quantitative analytical results on the outcome of the single reactions. Several automated chemistry examples clearly demonstrate the high efficiency of this combined system and its superiority compared to more classical approaches, e.g., HPLC analyses.

引用

页码：482 / 487

页数：6

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