Selective synthesis of 1,4,5-trisubstituted imidazoles from α-imino ketones prepared by N-heterocyclic-carbene-catalyzed aroylation

被引：10
|
作者：
Takashima, Ryo [1 ]
Tsunekawa, Kaoru [1 ]
Shinozaki, Maki [1 ]
Suzuki, Yumiko [1 ]
机构：
[1] Sophia Univ, Fac Sci & Technol, Dept Mat & Life Sci, Chiyoda Ku, 7-1 Kioicho, Tokyo 1028554, Japan
来源：
TETRAHEDRON | 2018年 / 74卷 / 18期
关键词：
N-Heterocyclic carbene; lmidazole; Aroylation; Chemoselective reduction; Annulation; IONIC LIQUIDS; ALDEHYDES;
D O I：
10.1016/j.tet.2018.03.048
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An alternative synthetic route to 1,4,5-trisubstituted imidazoles from alpha-imino ketone, which can be prepared from imidoyl chlorides and aromatic aldehydes via N-heterocycle carbene-catalyzed aroylation was developed. This methodology consists of simple transformations, allowing a rapid access to imidazole derivatives with various aryl substituents at the desired positions. (C) 2018 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2261 / 2267
页数：7
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