Role of Intrinsic Helicity Within N-Terminal Flanking Sequences on Huntingtin Aggregation Mechanisms

被引:0
|
作者
Ruff, Kiersten M. [1 ]
Garai, Kanchan [1 ]
Pappu, Rohit V. [1 ]
机构
[1] Washington Univ, St Louis, MO USA
关键词
D O I
10.1016/j.bpj.2013.11.2727
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
引用
收藏
页码:483A / 483A
页数:1
相关论文
共 50 条
  • [1] Role of (httNT) α-Helix Formation in Huntingtin N-Terminal Fragment Aggregation
    Mishra, Rakesh
    Kodali, Ravindra
    Roland, Bartholomew
    Wetzel, Ronald B.
    BIOPHYSICAL JOURNAL, 2012, 102 (03) : 254A - 255A
  • [2] THE ROLE OF N-TERMINAL PHOSPHORYLATION IN HUNTINGTIN'S OLIGOMERISATION, AGGREGATION AND TOXICITY
    Herrera, F.
    Branco dos Santos, J.
    Fleming Outeiro, T.
    JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2012, 83 : A8 - A8
  • [3] Lysine residues in the N-terminal huntingtin amphipathic α-helix play a key role in peptide aggregation
    Arndt, James R.
    Brown, Robert J.
    Burke, Kathleen A.
    Legleiter, Justin
    Valentine, Stephen J.
    JOURNAL OF MASS SPECTROMETRY, 2015, 50 (01): : 117 - 126
  • [4] Aggregation of N-terminal huntingtin is dependent on the length of its glutamine repeats
    Li, SH
    Li, XJ
    HUMAN MOLECULAR GENETICS, 1998, 7 (05) : 777 - 782
  • [5] Unmasking the roles of N- and C-terminal flanking sequences from exon 1 of huntingtin as modulators of polyglutamine aggregation
    Crick, Scott L.
    Ruff, Kiersten M.
    Garai, Kanchan
    Frieden, Carl
    Pappu, Rohit V.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (50) : 20075 - 20080
  • [6] N-terminal Huntingtin Knock-In Mice: Implications of Removing the N-terminal Region of Huntingtin for Therapy
    Liu, Xudong
    Wang, Chuan-En
    Hong, Yan
    Zhao, Ting
    Wang, Guohao
    Gaertig, Marta A.
    Sun, Miao
    Li, Shihua
    Li, Xiao-Jiang
    PLOS GENETICS, 2016, 12 (05):
  • [7] A comparison of the aggregation of different CFTR-derived peptides, the N-terminal huntingtin fragments and different fusion proteins encompassing the aggregation-prone sequences of CFTR and/or huntingtin
    Bak, D
    Jurkowska, M
    Dolowy, K
    Milewski, M
    FEBS JOURNAL, 2005, 272 : 364 - 365
  • [8] Does N-terminal huntingtin function as a "holdase' for inhibiting cellular protein aggregation?
    Sethi, Ratnika
    Tripathi, Neha
    Pallapati, Anusha R.
    Gaikar, Abhishek
    Bharatam, Prasad V.
    Roy, Ipsita
    FEBS JOURNAL, 2018, 285 (10) : 1791 - 1811
  • [9] Inhibition of polyglutamine aggregation by SIMILAR huntingtin N-terminal sequences: Prospective molecules for preclinical evaluation in Huntington's disease
    Burra, Gunasekhar
    Thakur, Ashwani Kumar
    BIOPOLYMERS, 2017, 108 (04)
  • [10] Modulation of Mutant Huntingtin N-Terminal Cleavage and Its Effect on Aggregation and Cell Death
    Katrin Juenemann
    Christina Weisse
    Denise Reichmann
    Christoph Kaether
    Cornelis F. Calkhoven
    Gabriele Schilling
    Neurotoxicity Research, 2011, 20 : 120 - 133