Screening for natural anticancer agents using a fission yeast bioassay

被引：6

作者：

Sanchez-Pico, Angeles ^{[1
]}

Leon-Gonzalez, Antonio J. ^{[2
]}

Martin-Cordero, Carmen ^{[2
]}

Daga, Rafael R. ^{[1
]}

机构：

[1] Univ Pablo de Olavide, CSIC, Ctr Andaluz Biol Desarrollo, Seville 41013, Spain

[2] Univ Seville, Fac Pharm, Dept Farmacol, Seville, Spain

来源：

PHYTOCHEMISTRY LETTERS | 2014年 / 8卷

关键词：

Corema album; Ericaceae; Fission yeast; Schizosaccharomyces pombe; Antiproliferative; Flavonoid; 2; 4; '-Dihydroxychalcone; (DHC); REPLICATION CHECKPOINT; DNA-DAMAGE; SCHIZOSACCHAROMYCES-POMBE; ABC TRANSPORTERS; RESISTANCE; CELLS; CDS1; CHK1; CHALCONES; PRODUCTS;

D O I：

10.1016/j.phytol.2013.09.011

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A fission-yeast bioassay guided screening on several plant extracts is carried out to search for anticancer agents, and an extract from leaves of Corema album (L.) D. Don (Ericaceae) is found to have antiproliferative activity. Further fractionation afforded 2 ',4 '-dihydroxychalcone (DHC) as the main cytotoxic compound present in the extract. Our detailed biological analysis shows that antiproliferative activity of this flavonoid is likely due to its ability to induce DNA damage which blocks cell cycle progression. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.

引用

页码：184 / 189

页数：6

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