Synthesis and antitumor, antityrosinase, and antioxidant activities of xanthone

被引：13
|
作者：
Zhou, Bei-Dou [1 ,2 ]
Zeng, Li-Lan [3 ]
Tong, Yu-Gui [4 ]
Fang, Jia-Ying [1 ,2 ]
Ruan, Zhi-Peng [1 ,2 ]
Zeng, Xiao-Yun [5 ]
Fang, Yuan-Yuan [1 ,2 ]
Xu, Gui-Fen [1 ,2 ]
Hu, Dong-Bao [6 ]
机构：
[1] Putian Univ, Sch Pharm & Med Technol, Putian 351100, Peoples R China
[2] Fujian Prov Univ, Putian Univ, Key Lab Pharmaceut Anal & Lab Med, Putian 351100, Peoples R China
[3] Agr Bur Xianyou Cty, Xianyou 351200, Peoples R China
[4] Putian Entry Exit Inspect & Quarantine Bur, Putian 351100, Peoples R China
[5] Shantou Univ, Med Coll, Dept Chem, Shantou 515041, Peoples R China
[6] Yuxi Normal Univ, Sch Chem Biol & Environm, Yuxi 653100, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2018年 / 20卷 / 05期
关键词：
Xanthone; synthesis; antitumor activity; antityrosinase; antioxidation; BIOLOGICAL EVALUATION; DERIVATIVES; ANTIBACTERIAL; CELLS; GROWTH; DESIGN; AGENTS;
D O I：
10.1080/10286020.2018.1454437
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Ten substituted 1,3-dihydroxyxanthones were synthesized in one step. The yields ranged from 40 to 76%. Compounds 8-10 were first reported. Next, the compounds' in vitro anti-proliferative activities against nine human cancer cell lines, antityrosinase, and antioxidant activities were evaluated. Compounds 1, 4, 6-7, and 9-10 exhibited enhanced cytotoxicity against certain cancer cells. Compounds 2, 8, 9, and 10 inhibited tyrosinase activity to a certain extent. In addition, compound 4 exhibited the best antioxidant activity, which was consistent with theoretical calculations. These results demonstrated that compounds 1-2, 4, and 6-10 were promising leads for further investigation. [GRAPHICS] .
引用
收藏
页码：467 / 476
页数：10
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