Suzuki-Miyaura Cross-Coupling Reaction Catalyzed by Supported Palladium Under Microwave Irradiation

Organic synthesis efficiency can take considerable advantage from microwave heating. Compared to conventional heating, it allows to improve the reactions speed and yield through an energy-efficient, clean, and easy-to-use processing tool. Transition-metal catalyzed cross-coupling reactions and in particular the Suzuki-Miyaura cross-coupling is powerful and widely used tool for the formation of carbon-carbon bonds. Cross coupling reactions are of large interest for the bonding of a broad range of functional groups, in particular biaryl groups, allowing for a strong stereoselectivity. In this paper, recent research results concerning the application of microwave heating in Suzuki-Miyaura cross-coupling reactions are reviewed with particular emphasis on reactions involving supported Pd as a catalyst.