Studies towards a total synthesis of the antiprogestine onapristone

被引：10
|
作者：
Enev, VS [1 ]
Petrov, OS [1 ]
Neh, H [1 ]
Nickisch, K [1 ]
机构：
[1] SCHERING AG,PROC RES,D-13342 BERLIN,GERMANY
来源：
TETRAHEDRON | 1997年 / 53卷 / 40期
关键词：
D O I：
10.1016/S0040-4020(97)00934-4
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Starting from the readily available Eder-Hajosh ketone 2 a stereoselective method for synthesis of arylated hydrindenone 14 was developed. One pot Li/NH3 reduction and trapping of the generated enolate with activated Michael acceptor gave a properly substituted BCD-ring precursor 22. Attempted B ring closure with the model compound 22 failed under various conditions. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码：13709 / 13718
页数：10
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