The influence of Annexin32, a new Ca2+-dependent phospholipid-binding protein, on coagulation time and thrombosis

被引：7
|
作者：
Zhang, Y [1 ]
Chen, RW [1 ]
Sun, SH [1 ]
机构：
[1] Second Mil Med Univ, Inst Med Biotechnol & Mol Genet, Dept Med Genet, Shanghai 200433, Peoples R China
来源：
SCIENCE IN CHINA SERIES C-LIFE SCIENCES | 2002年 / 45卷 / 02期
关键词：
annexins; coagulation time; thrombosis;
D O I：
10.1360/02yc9021
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The pharmacodynamics of Annexin32, a new Ca2+-dependent phospholipid-binding protein, was studied by measuring coagulation time in rabbits and venous thrombosis in rabbits and rats. Rabbits and rats were given Annexin32 by intravenous administration. Then Kaolin partial thromboplastin time (KPTT), thrombosis in vitro and in vivo were assayed. The results showed that KPTT of rabbits was prolonged (p < 0.01), and the length and weight of thrombus in vitro were reduced (p < 0.01) after administration of Annexin32 at 1 mg/kg. It also inhibited thrombosis in vivo and reduced the weight of venous thrombus significantly in rats (p < 0.01). All these results suggested that Annexin32 possesses the characteristic of antithrombotic effect and fewer side effects on coagulation time.
引用
收藏
页码：186 / 190
页数：5
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